Yoon Kwang Lee

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Nuclear hormone receptors regulate diverse metabolic pathways and the orphan nuclear receptor LRH-1 (also known as NR5A2) regulates bile acid biosynthesis. Structural studies have identified phospholipids as potential LRH-1 ligands, but their functional relevance is unclear. Here we show that an unusual phosphatidylcholine species with two saturated 12(More)
Small heterodimer partner (SHP, NR0B2) is involved in diverse metabolic pathways, including hepatic bile acid, lipid and glucose homeostasis, and has been implicated in effects on the peroxisome proliferator-activated receptor γ (PPARγ), a master regulator of adipogenesis and the receptor for antidiabetic drugs thiazolidinediones (TZDs). In this study, we(More)
Supplementary Figure 1. Specific activation of hLRH-1 by DLPC. a-c, Full length of human LRH-1 are activated by DLPC but not other PCs, lysoPCs, fatty acids, and PEs. Luciferase assays were performed with extracts of HeLa cells transfected with expression plasmids for human LRH-1 and LRH-1/SF-1 Luc reporter plasmid. Cells were treated with 100 µM of the(More)
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