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In a 4-cell stage C. elegans embryo, signaling by the P2 blastomere induces anterior-posterior polarity in the adjacent EMS blastomere, leading to endoderm formation. We have taken genetic and reverse genetic approaches toward understanding the molecular basis for this induction. These studies have identified a set of genes with sequence similarity to genes(More)
Mal de Debarquement Syndrome (MdDS) is an enigmatic neurotological disorder with high morbidity, psychosocial burden, and few treatment options. Fortunately, there has been recent growth in scientific interest in understanding the biological basis of and in treating MdDS. Recent studies using functional neuroimaging have shown increased glucose metabolism(More)
Mal de Debarquement Syndrome is a neurological disorder of motion perception, triggered by external motion. This study aimed to determine the importance of psychosocial factors in relation to depression and quality of life in Mal de Debarquement Syndrome. A total of 66 participants with self-reported Mal de Debarquement Syndrome completed quality-of-life,(More)
To determine how arterial spin labeling (ASL) measured perfusion relates to baseline metabolism, we compared resting state cerebral perfusion using pseudo-continuous ASL and cerebral glucose metabolism using (18)F-FDG PET in 20 normal volunteers. Greater regional metabolism relative to perfusion was observed in the putamen, orbitofrontal and temporal lobes,(More)
The presentation of acute vertigo may represent both a common benign disorder or a life threatening but rare one. Familiarity with the common peripheral vestibular disorders will allow the clinician to rapidly "rule-in" a benign disorder and recognize when further testing is required. Key features of vertigo required to make an accurate diagnosis are(More)
OBJECTIVE To investigate the clinical features and natural history of mal de debarquement (MdD). DESIGN Retrospective case review with follow-up questionnaire and telephone interviews. SETTING University Neurotology Clinic. PATIENTS Patients seen between 1980 and 2006 who developed a persistent sensation of rocking or swaying for at least 3 days after(More)
Mal de debarquement (MdD), the "sickness of disembarkment," occurs when habituation to background rhythmic movement becomes resistant to readaption to stable conditions and results in a phantom perception of self motion typically described as rocking, bobbing, or swaying. Although several studies have shown that brief periods of MdD are common in healthy(More)
OBJECTIVE To evaluate the association between migraine, episodic vertigo, and Ménière's disease in families. STUDY DESIGN Clinical report. SETTING University Neurotology Clinic. PATIENTS Index patients identified with Ménière's disease and migraine and their family members. INTERVENTION Structured interview to assess a diagnosis of migraine,(More)
OBJECTIVE Mal de debarquement syndrome (MdDS) is a chronic disorder of imbalance characterized by a feeling of rocking and swaying. The disorder starts after prolonged exposure to passive motion such as from a boat or plane. All medical treatment is palliative and symptoms that persist beyond 6 months show low likelihood of remission. This pilot study(More)