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We consider the channel assignment problem for multihop wireless networks in which nodes have multiple interfaces. Given the number of interfaces at each node and available channels in the system, we find a feasible channel assignment to improve network performance. Even when routing is given, finding a channel assignment for optimal performance is NP-hard.(More)
Accurate gene model annotation of reference genomes is critical for making them useful. The modENCODE project has improved the D. melanogaster genome annotation by using deep and diverse high-throughput data. Since transcriptional activity that has been evolutionarily conserved is likely to have an advantageous function, we have performed large-scale(More)
Broadcasting is a fundamental operation in wireless networks and plays an important role in the communication protocol design. In multihop wireless networks, however, interference at a node due to simultaneous transmissions from its neighbors makes it nontrivial to design a minimum-latency broadcast algorithm, which is known to be NP-complete. We present a(More)
Complex diseases are caused by a combination of genetic and environmental factors. Uncovering the molecular pathways through which genetic factors affect a phenotype is always difficult, but in the case of complex diseases this is further complicated since genetic factors in affected individuals might be different. In recent years, systems biology(More)
In this paper we study a well-known broadcasting heuristic for heterogeneous networks of workstations, called fastest node first. We show that this heuristic produces an optimal solution for minimizing the sum of all completion times and, in addition, produces a 1.5 approximation for the problem of minimizing the maximum completion time. We also develop a(More)
In complex diseases, various combinations of genomic perturbations often lead to the same phenotype. On a molecular level, combinations of genomic perturbations are assumed to dys-regulate the same cellular pathways. Such a pathway-centric perspective is fundamental to understanding the mechanisms of complex diseases and the identification of potential drug(More)