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—Secondary ion mass spectrometer (SIMS) oxygen isotope analyses were performed on 24 clasts, representing 9 clast types, in the Dar al Gani (DaG) 319 polymict ureilite with precisions better than 1‰. Olivine-rich clasts with typical ureilitic textures and mineral compositions have oxygen isotopic compositions that are identical to those of the monomict(More)
BACKGROUND Osteoporosis is the most prevalent skeletal disorder, characterized by a low bone mineral density (BMD) and bone structural deterioration, leading to bone fragility fractures. Accelerated bone resorption by osteoclasts has been established as a principal mechanism in osteoporosis. However, recent experimental evidences suggest that inappropriate(More)
Emerging evidence suggests that tumor-initiating cells (TICs) are the most malignant cell subpopulation in tumors because of their resistance to chemotherapy or radiation treatment. Targeting TICs may be a key innovation for cancer treatment. In this study, we found that PPARγ agonists inhibited the cancer stem cell-like phenotype and attenuated tumor(More)
The mammalian target of the rapamycin (mTOR) pathway, which drives cell proliferation, is frequently hyperactivated in a variety of malignancies. Therefore, the inhibition of the mTOR pathway has been considered as an appropriate approach for cancer therapy. In this study, we examined the roles of mTOR in the maintenance and differentiation of cancer(More)
BACKGROUND SSeCKS is a major protein kinase C substrate with kinase scaffolding and metastasis-suppressor activity whose expression is severely downregulated in Src- and Ras-transformed fibroblast and epithelial cells and in human prostate, breast, and gastric cancers. We previously used NIH3T3 cells with tetracycline-regulated SSeCKS expression plus a(More)
Hyperactivation of the transcriptional factor E2F1 occurs frequently in human cancers and contributes to malignant progression. E2F1 activity is regulated by proteolysis mediated by the ubiquitin-proteasome system. However, the deubiquitylase that controls E2F1 ubiquitylation and stability remains undefined. Here we demonstrate that the deubiquitylase POH1(More)
Chloride channels (CLCs) have been reported to be involved in plant adaptation to salt stress by regulating Cl− homeostasis. In this study, a putative CLC-encoding gene, CsCLCc, was isolated from trifoliate orange [Poncirus trifoliata (L.) Raf]. The deduced amino acids of CsCLCc share high identity with other CLC-like sequences, which also contain domains(More)
Boron (B) is an essential microelement for higher plants, and its deficiency is widespread around the world and constrains the productivity of both agriculture and forestry. In the last two decades, numerous studies on model or herbaceous plants have contributed greatly to our understanding of the complex network of B-deficiency responses and mechanisms for(More)
Boron efficiency of scion ‘Fengjie-72' is related to its less reduced boron concentration and distribution in leaves, achieved by decreasing the ratio of available boron in roots under boron-deficient conditions. Boron (B) deficiency is widespread in citrus orchards. Previous studies have demonstrated that the B-efficient navel orange scion ‘Fengjie-72'(More)
Emerging evidence suggests that tumor-initiating cells (TICs) are the most malignant cell subpopulation in tumors because of their resistance to chemotherapy or radiation treatment. Targeting TICs may be a key innovation for cancer treatment. In this study, we found that PPARc agonists inhibited the cancer stem cell-like phenotype and attenuated tumor(More)