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Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death
Immunogenic cell death (ICD)-associated immunogenicity can be evoked through reactive oxygen species (ROS) produced via endoplasmic reticulum (ER) stress. In this study, we generate a doubleExpand
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A photosensitive liposome with NIR light triggered doxorubicin release as a combined photodynamic‐chemo therapy system
  • Qingpo Li, W. Li, +8 authors Jian You
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 10 May 2018
&NA; The targeted drug delivery with the help of nanocarriers and the controlled drug release at the lesion sites are the most effective ways to enhance therapeutic efficacy and reduce side effects.Expand
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External Magnetic Field-Enhanced Chemo-Photothermal Combination Tumor Therapy via Iron Oxide Nanoparticles.
The development of multifunctional nanoplatforms based on magnetic nanoparticles (MNPs) has attracted increasing attention. MNPs especially exhibit excellent responsiveness under the guidance of anExpand
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Antitumor drug delivery modulated by a polymeric micelle with an upper critical solution temperature.
Thermally sensitive polymeric nanocarriers were developed to optimize the release profile of encapsulated compounds to improve treatment efficiency. However, when referring to thermally sensitiveExpand
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Redox-responsive polymer-drug conjugates based on doxorubicin and chitosan oligosaccharide-g-stearic acid for cancer therapy.
Here, a biodegradable polymer-drug conjugate of doxorubicin (DOX) conjugated with a stearic acid-grafted chitosan oligosaccharide (CSO-SA) was synthesized via disulfide linkers. The obtainedExpand
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Gene therapy of endometriosis introduced by polymeric micelles with glycolipid-like structure.
To reduce the side effects and improve the lack of clinical treatment countermeasures in endometriosis chemotherapy, a polymeric micelle gene delivery system composed of lipid grafted chitosanExpand
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Near-Infrared Light-Sensitive Liposomes for the Enhanced Photothermal Tumor Treatment by the Combination with Chemotherapy
PurposeTo develop a near-infrared (NIR) light-sensitive liposome, which contains hollow gold nanospheres (HAuNS) and doxorubicin (DOX), and evaluate their potential utility for enhancing antitumorExpand
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Sustained release of anti‐PD‐1 peptide for perdurable immunotherapy together with photothermal ablation against primary and distant tumors
  • Lihua Luo, J. Yang, +10 authors Jian You
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 28 May 2018
ABSTRACT Immune checkpoint PD‐1/PD‐L1 blockade has emerged as a successful immunotherapy strategy for treating several types of malignant tumors. A constant and proper drug concentration during theExpand
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Appropriate Size of Magnetic Nanoparticles for Various Bioapplications in Cancer Diagnostics and Therapy.
The development of multifunctional nanoparticles has attracted increasing attention. The versatility of nanoparticles largely depends on their physiochemical properties (especially size). However,Expand
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Synchronous delivery of oxygen and photosensitizer for alleviation of hypoxia tumor microenvironment and dramatically enhanced photodynamic therapy
Abstract Photosensitizer, proper laser irradiation, and oxygen are essential components for effective photodynamic therapy (PDT) in clinical cancer therapy. However, native hypoxic tumoralExpand
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