Yongyun Wang

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  • Alexander M Taylor, Alexandre Côté, +41 authors Brian K Albrecht
  • ACS medicinal chemistry letters
  • 2016
CBP and EP300 are highly homologous, bromodomain-containing transcription coactivators involved in numerous cellular pathways relevant to oncology. As part of our effort to explore the potential therapeutic implications of selectively targeting bromodomains, we set out to identify a CBP/EP300 bromodomain inhibitor that was potent both in vitro and in(More)
To seek a method and its potential algorithm of the differentiation of the health status and the intelligent decision for the road-line of the transformation among different healthy status, three procedures were designed: 1. Extensible Markup Language (XML) documents were tree-shape-like structured and modeled from a kind of rule for the distribution of(More)
The biological function of bromodomains, epigenetic readers of acetylated lysine residues, remains largely unknown. Herein we report our efforts to discover a potent and selective inhibitor of the bromodomain of cat eye syndrome chromosome region candidate 2 (CECR2). Screening of our internal medicinal chemistry collection led to the identification of a(More)
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