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Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells.
Preparation, pharmacokinetics and pharmacodynamics of ophthalmic thermosensitive in situ hydrogel of betaxolol hydrochloride.
TAT-modified nanosilver for combating multidrug-resistant cancer.
Low-molecular-weight protamine-modified PLGA nanoparticles for overcoming drug-resistant breast cancer.
Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient
Human induced pluripotent stem cell-derived cardiomyocytes from a BrS patient are used to evaluate the roles of Na+ currents and transient outward K+ currents in BrS induced action potential (AP) changes and indicate that a repolarization deficit could be a mechanism underlying BrS.
Cell-penetrating albumin conjugates for enhanced doxorubicin delivery
The studies with human xenograft tumors in nude mice further demonstrated the enhanced antitumor efficacy and reduced side effects of the cell-penetrating albumin-assisted DOX delivery strategy, indicating the promise of this delivery system.
Microneedle-Assisted Transdermal Delivery of Etanercept for Rheumatoid Arthritis Treatment
A hyaluronic acid crosslinked microneedle system was constructed as the transdermal alternative to deliver etanercept and possessed sufficient mechanical strength, good biocompatibility, little influence on the bioactivity of EN, and high anti-inflammatory efficacy.
Pharmacokinetics, tissue distribution and anti-tumor effect of low density lipoprotein peptide conjugated submicron emulsions.
Multifunctional gold nanorods and docetaxel-encapsulated liposomes for combined thermo- and chemotherapy
- H. Hua, N. Zhang, Yongxing Zhao
- Biology, ChemistryInternational journal of nanomedicine
- 25 October 2017
The multifunctional GNRs/DocL-R showed enhanced intracellular entrance, increased accumulation in the implanted tumor region, and the highest tumor inhibition in vitro and in vivo, and was a potential cancer treatment via combined chemo- and thermotherapy.
Low Density Lipoprotein Peptide-Conjugated Gold Nanorods for Combating Gastric Cancer.
- N. Zhang, Dongxue Zhu, Feng Li, H. Hua, Xin Tian, Yongxing Zhao
- Biology, ChemistryJournal of biomedical nanotechnology
- 1 February 2017
RLT-AuNRs may be a viable anti-tumor agent for gastric cancer because it possessed higher in vivo safety than did DOX and Histological results showed no tissue toxicity of RLT.