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A microarray for microRNA profiling in mouse testis tissues.
The data indicated specific miRNAAs expression in immature mouse testis and suggested that miRNAs have a role in regulating spermatogenesis, which is suggested by MiRscan performing miRNA target scanning.
Piwil2 Suppresses P53 by Inducing Phosphorylation of Signal Transducer and Activator of Transcription 3 in Tumor Cells
Human piwil2, or Hili represses the tumor suppressor P53 in human cancer cells and plays a role in anti-apoptosis in tumor cells possessing P53 as a positive regulator of STAT3 signaling pathway, providing novel sights into roles of Piwil2 in tumorigenesis.
Microarray profiling of microRNAs expressed in testis tissues of developing primates
- N. Yan, Yi-lu Lu, +8 authors Yongxin Ma
- Biology, MedicineJournal of Assisted Reproduction and Genetics
- 26 February 2009
PicTar and TargetScan prediction tools predicted a number of target mRNAs, and some of these target genes predicted by miRNAs have been shown to associate with spermatogenesis.
Identification of piRNAs in Hela cells by massive parallel sequencing.
It is demonstrated that HILI along with piRNAs plays a role in LINE1 suppression in HeLa cancer cell line.
Zili Inhibits Transforming Growth Factor-β Signaling by Interacting with Smad4*
- Huaqin Sun, D. Li, +7 authors Yongxin Ma
- Biology, MedicineThe Journal of Biological Chemistry
- 9 December 2009
This work shows that zili plays a role in early embryogenesis beyond germ line as a novel negative regulator of TGF-β signaling, extending the function of Piwi proteins in vertebrates.
Y chromosome haplogroups may confer susceptibility to partial AZFc deletions and deletion effect on spermatogenesis impairment.
The findings indicate that some monophyletic Y chromosomes may be associated with predisposition to specific subtypes of partial AZFc deletion and adverse effect on spermatogenesis in a Chinese population.
Identification of novel mutations in Chinese Hans with autosomal dominant polycystic kidney disease
- Chao-wen Yu, Yuan Yang, +7 authors Si-zhong Zhang
- Biology, MedicineBMC Medical Genetics
- 20 December 2011
Mutation study of PKD1 and PKD2 genes in Chinese Hans with ADPKD may contribute to a better understanding of the genetic diversity between different ethnic groups and enrich the mutation database.
Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide.
- Yongxin Ma, Si-zhong Zhang, +8 authors A. Milunsky
- Biology, MedicineMolecular human reproduction
Results of Northern blot and RT-PCR analyses of RNA extracted from human tissues revealed that the gene is only expressed in fertile adult testes, but not in azoospermictestes, fetal testes nor in other human tissues.
Some single-nucleotide polymorphisms of the TSSK2 gene may be associated with human spermatogenesis impairment.
To explore the possible association between mutations in the TSSK2 gene and idiopathic infertility in humans, mutation screening of the gene in 494 patients with azoospermia or severe oligozoospermia and 357 fertile controls was performed using denaturing high-performance liquid chromatography and DNA sequencing.
Evidence for a predisposing background for CAG expansion leading to HTT mutation in a Chinese population
- M. Ma, Yuan Yang, +6 authors Si-zhong Zhang
- Medicine, BiologyJournal of the Neurological Sciences
- 15 November 2010
The findings indicate that HTT mutation is likely of multiple origins in the Chinese population, and among the origins, more new HTT mutations may arise from the ( CCG)10 than from other CCG alleles, which suggests that the (CCG) 10 allele may represent a predisposing background for CAG expansion in Chinese populations.