Yongxiang Wang

Publications102
h-index29
Citations2,329
Highly Influential Citations65
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Activation of Spinal Glucagon-Like Peptide-1 Receptors Specifically Suppresses Pain Hypersensitivity
TLDR
The results illustrate a novel spinal dorsal horn microglial GLP-1R/β-endorphin inhibitory pathway in a variety of pain hypersensitivity states that potently alleviated formalin, peripheral nerve injury, bone cancer, and diabetes-induced hypers sensitivity states.
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Methylglyoxal mediates streptozotocin-induced diabetic neuropathic pain via activation of the peripheral TRPA1 and Nav1.8 channels.
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Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats
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Site‐specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity
TLDR
Exenatide is a 39‐amino‐acid peptide widely used to manage type 2 diabetes mellitus but has a short plasma half‐life and requires a twice daily injection regime, so maleimide‐polyethylene glycol is used to induce site‐specific PEGylation.
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Effects of intrathecal administration of ziconotide, a selective neuronal N-type calcium channel blocker, on mechanical allodynia and heat hyperalgesia in a rat model of postoperative pain
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Geniposide and its iridoid analogs exhibit antinociception by acting at the spinal GLP-1 receptors
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Pain-related behavior following REM sleep deprivation in the rat: Influence of peripheral nerve injury, spinal glutamatergic receptors and nitric oxide
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Peptidic exenatide and herbal catalpol mediate neuroprotection via the hippocampal GLP-1 receptor/β-endorphin pathway.
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Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., exhibits potent and specific antinociception in chronic pain by acting at spinal α3 glycine receptors
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Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat
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