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Activation of Spinal Glucagon-Like Peptide-1 Receptors Specifically Suppresses Pain Hypersensitivity
TLDR
The results illustrate a novel spinal dorsal horn microglial GLP-1R/β-endorphin inhibitory pathway in a variety of pain hypersensitivity states that potently alleviated formalin, peripheral nerve injury, bone cancer, and diabetes-induced hypers sensitivity states.
Site‐specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity
TLDR
Exenatide is a 39‐amino‐acid peptide widely used to manage type 2 diabetes mellitus but has a short plasma half‐life and requires a twice daily injection regime, so maleimide‐polyethylene glycol is used to induce site‐specific PEGylation.
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