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Activation of Spinal Glucagon-Like Peptide-1 Receptors Specifically Suppresses Pain Hypersensitivity
The results illustrate a novel spinal dorsal horn microglial GLP-1R/β-endorphin inhibitory pathway in a variety of pain hypersensitivity states that potently alleviated formalin, peripheral nerve injury, bone cancer, and diabetes-induced hypers sensitivity states.
Methylglyoxal mediates streptozotocin-induced diabetic neuropathic pain via activation of the peripheral TRPA1 and Nav1.8 channels.
Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats
Site‐specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity
Exenatide is a 39‐amino‐acid peptide widely used to manage type 2 diabetes mellitus but has a short plasma half‐life and requires a twice daily injection regime, so maleimide‐polyethylene glycol is used to induce site‐specific PEGylation.
Effects of intrathecal administration of ziconotide, a selective neuronal N-type calcium channel blocker, on mechanical allodynia and heat hyperalgesia in a rat model of postoperative pain
Geniposide and its iridoid analogs exhibit antinociception by acting at the spinal GLP-1 receptors
Pain-related behavior following REM sleep deprivation in the rat: Influence of peripheral nerve injury, spinal glutamatergic receptors and nitric oxide
Peptidic exenatide and herbal catalpol mediate neuroprotection via the hippocampal GLP-1 receptor/β-endorphin pathway.
Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., exhibits potent and specific antinociception in chronic pain by acting at spinal α3 glycine receptors