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MicroRNAs (miRNAs) are a class of small non-coding RNAs (19 – 25 nucleotides) that regulate gene expression in viruses, plants, and animals. Over 700 miRNAs are already identified in humans with thousands more expected to be found. Accumulated studies have reported distinct miRNA expression patterns in various human diseases, showing great potential of(More)
Supramolecular protein assemblies offer novel nanoscale architectures with molecular precision and unparalleled functional diversity. A key challenge, however, is to create precise nano-assemblies of functional proteins with both defined structures and a controlled number of protein-building blocks. Here we report a series of supramolecular green(More)
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) analysis of immuno-captured target protein efficiently complements conventional immunoassays by offering rich molecular information such as protein isoforms or modifications. Direct immobilization of antibodies on MALDI solid support enables both target enrichment(More)
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