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Autosomal recessive juvenile parkinsonism (AR-JP) is an early-onset form of Parkinson's disease characterized by motor disturbances and dopaminergic neurodegeneration. To address its underlying molecular pathogenesis, we generated and characterized loss-of-function mutants of Drosophila PTEN-induced putative kinase 1 (PINK1), a novel AR-JP-linked gene.(More)
PTEN-induced putative kinase 1 (PINK1) and Parkin, encoded by their respective genes associated with Parkinson's disease (PD), are linked in a common pathway involved in the protection of mitochondrial integrity and function. However, the mechanism of their interaction at the biochemical level has not been investigated yet. Using both mammalian and(More)
This study investigated human-induced pluripotent stem cell (hiPSC) -derived neurons for their ability to secrete neurotransmitters in an activity-dependent manner, the fundamental property required for chemical neurotransmission. Cultured hiPSC neurons showed KCl stimulation of activity-dependent secretion of catecholamines--dopamine (DA), norepinephrine(More)
Voltage-dependent anion channel (VDAC) has been suggested to be a mediator of mitochondrial-dependent cell death induced by Ca(2+) overload, oxidative stress and Bax-Bid activation. To confirm this hypothesis in vivo, we generated and characterized Drosophila VDAC (porin) mutants and found that Porin is not required for mitochondrial apoptosis, which is(More)
In this paper we present a hybrid model for real-time query processing over data stream collected by mobile air quality sensors. First, we introduce a novel indexing scheme for representing air quality and use it for generating and evaluating a static model over a yearly dataset. Then, this model is combined with a dynamic nearest-neighbor approach for(More)
In location-based social Q&A, the questions related to a local community (e.g. local services and places) are typically answered by local residents (i.e. who have the local knowledge). In this work, we wanted to deepen our understanding of the localness of knowledge sharing through investigating the topical and typological patterns related to the(More)
The evidential belief function (EBF) model was applied and validated for analysis of groundwater-productivity potential (GPP) in Boryeong and Pohang cities, agriculture region in Korea using geographic information systems (GIS). Data about related factors, including topography, lineament, geology, forest, soil, and groundwater data were collected and input(More)
We present <i>Mobile Observatory</i>, a mobile air quality monitoring application that provides evaluation of air quality of the city of Zurich, Switzerland. As <i>Mobile Observatory</i> utilizes air quality data gathered by sensors mounted on around 10 trams in Zurich, it is able to provide neighborhood-level air quality information within the city. In(More)
NIE (newspaper in education), which is the study utilizing newspaper-based educational resources in the classroom, has been pursued for a long time. Traditional NIE allows only one-way interaction and available media are limited. In addition, it has difficulty in capturing the latest “hot” issues or recognizing public opinions. In this paper, we propose a(More)