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We investigated the biophysical mechanism of low-frequency drift in blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) (0.00-0.01 Hz), by exploring its spatial distribution, dependence on imaging parameters, and relationship with task-induced brain activation. Cardiac and respiratory signals were concurrently recorded during(More)
PURPOSE To evaluate the capability of a dual-cooling technique in suppressing motion artifact and to evaluate the feasibility of the noninvasive muscle fibers tracking using DTI during chick embryonic development. MATERIALS AND METHODS Fifteen eggs were divided into three groups of 5 eggs each (one group for each imaging sequence), and eggs were imaged(More)
BACKGROUND Investigations into the mechanism of diffuse retinal edema in diabetic subjects have been limited by a lack of animal models and techniques that co-localized retinal thickness and hydration in vivo. In this study we test the hypothesis that a previously reported supernormal central retinal thickness on MRI measured in experimental diabetic(More)
For more than a decade, turbo spin echo (TSE) pulse sequences have been suggested as an alternative to echo planar imaging (EPI) sequences for fMRI studies. Recent development in parallel imaging has renewed the interest in developing more robust TSE sequences for fMRI. In this study, a modified half Fourier acquisition single-shot TSE (mHASTE) sequence has(More)
INTRODUCTION The piriform cortex and cortical amygdala (PCA) and the orbitofrontal cortex (OFC) are considered olfactory-related brain regions. This study aims to elucidate the normal volumes of PCA and OFC of each age groups (20.0-70.0 year old), and whether the volumes of PCA and OFC decline with increasing age and diminishing olfactory function. (More)
Magnetic resonance imaging is a noninvasive method of evaluating embryonic development. Diffusion tensor imaging (DTI), based on the directional diffusivity of water molecules, is an established method of evaluating tissue structure. Yet embryonic motion degrades the in vivo acquisition of long-duration DTI. We used a dual-cooling technique to avoid motion(More)
Magnetic Resonance properties of tissues can be quantified in several respects: relaxation processes, density of imaged nuclei, magnetism of environmental molecules, etc. In this paper, we propose a new comprehensive approach to obtain 3D high resolution quantitative maps of arbitrary body districts, mainly focusing on the brain. The theory presented makes(More)
_________________________________________ Advisor Date _________________________________________ _________________________________________ _________________________________________ _________________________________________ ii DEDICATION This dissertation is dedicated to my parents: Jianwu Liu Guizhi Xi iii ACKNOWLEDGMENTS I would like to thank three(More)
Formation of operational neural networks is one of the most significant accomplishments of human fetal brain growth. Recent advances in functional magnetic resonance imaging (fMRI) have made it possible to obtain information about brain function during fetal development. Specifically, resting-state fMRI and novel signal covariation approaches have opened up(More)
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