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HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma.
BACKGROUND Long noncoding RNA Hox transcript antisense intergenic RNA (HOTAIR) has been characterized as a negative prognostic factor in breast and colon cancer patients. The clinical significance… Expand
RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas.
Studies of gene rearrangements and the consequent oncogenic fusion proteins have laid the foundation for targeted cancer therapy. To identify oncogenic fusions associated with glioma progression, we… Expand
MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma
- Chun-zhi Zhang, Jun-xia Zhang, +10 authors Chunsheng Kang
- Biology, Medicine
- Molecular Cancer
- 2 September 2010
BackgroundMiR-221 and miR-222 (miR-221/222) are frequently up-regulated in various types of human malignancy including glioblastoma. Recent studies have reported that miR-221/222 regulate cell growth… Expand
MicroRNA-7 regulates glioblastoma cell invasion via targeting focal adhesion kinase expression.
BACKGROUND Invasion growth is the most characteristic biological phenotype of glioblastoma, but the molecular mechanism in glioma cell invasion is poorly understood. Recent data have showed that… Expand
MiR-128 Inhibits Tumor Growth and Angiogenesis by Targeting p70S6K1
MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. In this study, we showed that miR-128… Expand
MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2
- Xie-feng Wang, Zhu-mei Shi, +9 authors Yongping You
- Biology, Medicine
- Journal of Cancer Research and Clinical Oncology
- 1 April 2012
PurposeRecently, several microRNAs (miRNAs) were reported to be involved in the modulation of glioma development. The aim of our study was to determine the effect of miR-181d on the growth of glioma… Expand
Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN.
BACKGROUND Altered expression of micro(mi)RNAs has been shown to be associated with tumorigenesis and tumor progression. The expression of phosphatase and tensin homolog (PTEN) plays an important… Expand
Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth
Glioblastoma stem cells (GSCs) are implicated in tumor neovascularization, invasiveness, and therapeutic resistance. To illuminate mechanisms governing these hallmark features, we developed a de novo… Expand
MiR-143 acts as a tumor suppressor by targeting N-RAS and enhances temozolomide-induced apoptosis in glioma
Therapeutic applications of microRNAs (miRNAs) in RAS-driven glioma were valuable, but their specific roles and functions have yet to be fully elucidated. Here, we firstly report that miR-143… Expand
Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma.
BACKGROUND Aberrant activation of beta-catenin/TCF4 and STAT3 signaling in glioblastoma multiforme (GBM) has been reported. However, the molecular mechanisms related to this process are still poorly… Expand