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Structure of the Protein Phosphatase 2A Holoenzyme
Protein Phosphatase 2A (PP2A) plays an essential role in many aspects of cellular physiology. The PP2A holoenzyme consists of a heterodimeric core enzyme, which comprises a scaffolding subunit and aExpand
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Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
The serine/threonine phosphatase protein phosphatase 2A (PP2A) plays an essential role in many aspects of cellular functions and has been shown to be an important tumor suppressor. The core enzyme ofExpand
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Structural Mechanism of Demethylation and Inactivation of Protein Phosphatase 2A
Protein phosphatase 2A (PP2A) is an important serine/threonine phosphatase that plays a role in many biological processes. Reversible carboxyl methylation of the PP2A catalytic subunit is anExpand
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The structural basis for tight control of PP2A methylation and function by LCMT-1.
Proper formation of protein phosphatase 2A (PP2A) holoenzymes is essential for the fitness of all eukaryotic cells. Carboxyl methylation of the PP2A catalytic subunit plays a critical role inExpand
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Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40
  • Y. Chen, Y. Xu, +6 authors Y. Shi
  • Medicine, Biology
  • Nature Structural &Molecular Biology
  • 2007
The small t antigen (ST) of DNA tumor virus SV40 facilitates cellular transformation by disrupting the functions of protein phosphatase 2A (PP2A) through a poorly defined mechanism. The crystalExpand
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Methylation-Dependent Binding of the Epstein-Barr Virus BZLF1 Protein to Viral Promoters
The switch between latent and lytic Epstein-Barr virus (EBV) infection is mediated by the viral immediate-early (IE) protein, BZLF1 (Z). Z, a homologue of c-jun that binds to AP1-like motifs (ZREs),Expand
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Structure and mechanism of the phosphotyrosyl phosphatase activator.
Phosphotyrosyl phosphatase activator (PTPA), also known as PP2A phosphatase activator, is a conserved protein from yeast to human. Here we report the 1.9 A crystal structure of human PTPA, whichExpand
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PP2A as a master regulator of the cell cycle
Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell cycle,Expand
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Structural basis of protein phosphatase 2A stable latency
The catalytic subunit of protein phosphatase 2A (PP2Ac) is stabilized in a latent form by α4, a regulatory protein essential for cell survival and biogenesis of all PP2A complexes. Here we report theExpand
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Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation
The B″/PR72 family of protein phosphatase 2A (PP2A) is an important PP2A family involved in diverse cellular processes, and uniquely regulated by calcium binding to the regulatory subunit. The PR70Expand
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