Yongliang Yang

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Collective cell migration plays essential roles in a wide spectrum of biological processes, such as embryogenesis, tissue regeneration, and cancer metastasis. Numerous wound-healing assays based on mechanical, chemical, optical, and electrical approaches have been developed to create model "wounds" in cell monolayers to study the collective cell migration(More)
Systematic manipulation of a cell microenvironment with micro- and nanoscale resolution is often required for deciphering various cellular and molecular phenomena. To address this requirement, we have developed a plasma lithography technique to manipulate the cellular microenvironment by creating a patterned surface with feature sizes ranging from 100 nm to(More)
State departments of transportation (DOTs), as well as national agencies in many countries, invest heavily in personnel and equipment to collect the data supporting the estimation of Average Annual Daily Traffic (AADT) and Vehicle Distance Traveled (VDT). Satellite-and air-based imagery can provide additional data for estimation and offers certain(More)
Silicon content in hot metal in the iron-making process has been used as a major indicator of the internal thermal state in blast furnace for many years. Due to the harsh environment in the blast furnace, how to measure the silicon content in hot metal is quite difficult. Many efforts have been made on the estimation of the silicon content in hot metal. In(More)
The accurate prediction of protein-ligand binding is of great importance for rational drug design. We present herein a novel docking algorithm called as FIPSDock, which implements a variant of the Fully Informed Particle Swarm (FIPS) optimization method and adopts the newly developed energy function of AutoDock 4.20 suite for solving flexible protein-ligand(More)
When blood vessels are injured, leader cells emerge in the endothelium to heal the wound and restore the vasculature integrity. The characteristics of leader cells during endothelial collective migration under diverse physiological conditions, however, are poorly understood. Here we investigate the regulation and function of endothelial leader cells by(More)
— One of the major limitations for Atomic Force Microscopy (AFM) based nanoparticle pushing is that AFM only has one sharp tip as the end-effector. The interaction force between the nanoparticle and the tip is applied through a single point, which often leads the AFM tip to slip-away from the nanoparticle due to their small touch area. Then several minutes(More)
— A novel method based on vibration-mode of the atomic force microscope (AFM) for nanoimaging and nanomanipulation is introduced in this paper. With this approach, the amplitude of OMSPV (opto-electronic measurement signal of probe vibration) can be used as a feedback signal to detect and control the operation state under vibration-mode. By controlling the(More)
Three new virtual databases have been developed for use with the bond-orientation-based database searching program CAVEAT. These consist of a database of trisubstituted monocyclic hydrocarbons having ethyl, vinyl, and phenyl substituents; a database of unsubstituted bicyclic hydrocarbons; and a database of core structures from established combinatorial(More)