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Inhibitor Discovery of Full-Length New Delhi Metallo-β-Lactamase-1 (NDM-1)
TLDR
Flexible docking and quantum mechanics study revealed electrostatic interactions between the sulfur atom of thiophene-carboxylic acid derivatives and the zinc ion of NDM-1, along with hydrogen bond between inhibitor and His189 of N DM-1 and the interaction models proposed here can be used in rational design of NDB-1 inhibitors. Expand
Microbial generation of nocathiacin acid from nocathiacin I.
TLDR
This is the first report on the generation of nocathiacin acid through microbial conversion in situ, and the present approach is more effective and could be broadly applied in the production of novel derivatives of microbial secondary metabolites. Expand
Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa
TLDR
Pseudomonas aeruginosa pmrB mutations in CF patients are proposed to be subject to an evolutionary trade-off, leading to enhanced colonisation potential, CFTR inhibition, and resistance to host defences, but also to increased susceptibility to antibiotics. Expand
Genetically enhanced lysozyme evades a pathogen derived inhibitory protein.
TLDR
E engineering hLYZ for broad-spectrum evasion of proteinaceous inhibitors will require consideration of the complex and varied determinants that underlie molecular recognition by these emerging virulence factors. Expand
Globally deimmunized lysostaphin evades human immune surveillance and enables highly efficacious repeat dosing
TLDR
A deimmunized lysostaphin biotherapy evades detrimental antidrug immune reactions and has improved efficacy for MRSA infections, providing significant anti-MRSA protection for animals that were immune experienced to the wild-type enzyme. Expand
Separation of structurally similar nocathiacin analogues by reversed phase chromatography.
TLDR
A simple and effective chromatographic method to separate and purify nocathiacin acid from its structural analogue nocATHiacin I was developed and offers a new methodology for the separation of structurally closely related secondary metabolites. Expand
Going native: Direct high throughput screening of secreted full-length IgG antibodies against cell membrane proteins
TLDR
GMD-FACS can overcome many of the limitations associated with conventional screening methods for antibody libraries and has the potential to contribute to antibody discovery and engineering for difficult targets, such as ion channels and G protein-coupled receptors. Expand
Deimmunized Lysostaphin Synergizes with Small-Molecule Chemotherapies and Resensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics
TLDR
Analysis of the antibacterial potential exhibited by F12, an innovative anti-MRSA lysin that has been genetically engineered to evade detrimental antidrug immune responses in human patients, suggests that combinations of F12 and SOC antibiotics are a promising new approach to treating refractory S. aureus infections. Expand
Pathogenesis and Prevention of Postoperative Endophthalmitis after Cataract Surgery from 2004 to 2016 in the Single-Center of the Guangming Project
TLDR
The incidence of postoperative endophthalmitis after cataract surgery is 0.079%, and can be further reduced by providing patients with clear pre- and postoperative medical and behavioral instructions to ensure that medications are taken properly, and that inappropriate activities are avoided. Expand