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Novel Strategy for Preparing Dual-Modality Optical/PET Imaging Probes via Photo-Click Chemistry.
- Lingyi Sun, Jiule Ding, W. Xing, Yongkang Gai, Jing Sheng, D. Zeng
- Biology, ChemistryBioconjugate chemistry
- 27 April 2016
A novel concise and generic strategy for preparing dual-modality optical/PET imaging probes via photo-click chemistry was developed, in which the diazole photo- click linker functioned not only as a bridge between the targeting-ligand and the PET imaging moiety, but also as the fluorophore for optical imaging.
Red blood cell membrane-coated upconversion nanoparticles for pretargeted multimodality imaging of triple-negative breast cancer.
Upconversion nanoparticles (UCNPs) have been widely employed for tumor imaging using magnetic resonance imaging (MRI) and upconversion luminescence (UCL) imaging. The short blood clearance time and…
One-pot synthesis of a microporous organosilica-coated cisplatin nanoplatform for HIF-1-targeted combination cancer therapy
Both in vitro and in vivo results suggested that this core-shell nanostructured cisplatin delivery system represented a highly efficacious and promising nanoplatform for the synergistic delivery of combination therapies involving cisplinatin.
Cyclic reactions-mediated self-supply of H2O2 and O2 for cooperative chemodynamic/starvation cancer therapy.
Co-delivery of Doxorubicin and Bmi1 siRNA by Folate Receptor Targeted Liposomes Exhibits Enhanced Anti-Tumor Effects in vitro and in vivo
Results suggest that Bmi1 is an effective therapeutic target for siRNA based cancer treatment that can be further improved by co-delivery of DOX through targeted liposomes.
A Solid Lipid Coated Calcium Peroxide Nanocarrier Enables Combined Cancer Chemo/Chemodynamic Therapy with O2/H2O2 Self-Sufficiency.
Evaluation of an Integrin αvβ3 and Aminopeptidase N Dual-receptor Targeting Tracer for Breast Cancer Imaging.
68Ga-NGR-RGD, a CD13 and αvβ3 dual-receptor targeting tracer showed higher binding avidities, targeting efficiency, and longer tumor retention time compared with monomeric 68Ga -NGR and 68Ga-R GD, an ideal candidate for future clinical translation.
A thiopyrylium salt for PET/NIR‐II tumor imaging and image‐guided surgery
XB1034 is a promising molecular imaging probe for tumor diagnosis and treatment that provides excellent sensitivity and high temporal resolution NIR‐II imaging in mice bearing tumors developed from human breast cancer cells MDA‐MB‐231.
A head-to-head comparison of 68Ga-DOTA-FAPI-04 and 18F-FDG PET/MR in patients with nasopharyngeal carcinoma: a prospective study
68Ga-FAPI outperforms 18F-FDG in delineating the primary tumor and detecting suspected distant metastases, particularly in the evaluation of skull-base and intracranial invasion, suggesting 68Ga- FAPI hybrid PET/MR has the potential to serve as a single-step staging modality for patients with NPC.
68Ga-DOTA-FAPI-04 PET/MR in the Evaluation of Gastric Carcinomas: Comparison with 18F-FDG PET/CT
68Ga-FAPI PET/MR outperformed 18F-FDG PET/CT in visualizing the primary and most metastatic lesions of gastric cancer and might be a promising method, with the potential of replacing 18F -FDGPET/CT.