Yongkai Wu

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BACKGROUND It has been shown that 14-3-3 σ serves as a tumor suppressor gene, and is downregulated in various tumor tissues. However, the role of 14-3-3 σ during the initiation and progression of lung squamous cell carcinoma (SqCC) is not well understood. METHODS The expression status of 14-3-3 σ in archival tissue samples from 40 lung SqCC patients (36(More)
Discrimination discovery is to unveil discrimination against a specific individual by analyzing the historical dataset. In this paper, we develop a general technique to capture discrimination based on the legally grounded situation testing methodology. For any individual, we find pairs of tuples from the dataset with similar characteristics apart from(More)
Discrimination discovery and prevention/removal are increasingly important tasks in data mining. Discrimination discovery aims to unveil discriminatory practices on the protected attribute (e.g., gender) by analyzing the dataset of historical decision records, and discrimination prevention aims to remove discrimination by modifying the biased data before(More)
In this paper, we investigate the problem of discovering both direct and indirect discrimination from the historical data, and removing the discriminatory effects before the data is used for predictive analysis (e.g., building classifiers). The main drawback of existing methods is that they cannot distinguish the part of influence that is really caused by(More)
Non-small cell lung cancer (NSCLC) is highly prevalent and needs novel therapies. Melanoma-associated antigen 3 (MAGE-A3) is a lung cancer antigen and calreticulin (CALR) can modulate immune responses. Our previous study has shown that up-regulated MAGE-A3 and CALR expression inhibits the proliferation and invasion of glioma cells. In this study, we(More)
Discrimination discovery and prevention has received intensive attention recently. Discrimination generally refers to an unjustified distinction of individuals based on their membership, or perceived membership, in a certain group, and often occurs when the group is treated less favorably than others. However, existing discrimination discovery and(More)
Heat shock protein 90-beta (Hsp90-β) is associated with cell proliferation, differentiation and apoptosis and has been investigated as a prognostic factor in many cancers. However, Hsp90-β protein expression in lung adenocarcinoma (ADC) has not been thoroughly elucidated. The aim of this study was to determine the relationship between Hsp90-β expression,(More)
BACKGROUND AND OBJECTIVE Decorin is a protein component of the extracellular matrix. It has been proven that decorin plaid an important role in matrix assembly. The protein is also capable of suppressing tumor cell growth. The aim of this study is to examine the protein levels of decorin in tissue samples of non-small cell lung cancer (NSCLC) patients and(More)