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Discrimination discovery is to unveil discrimination against a specific individual by analyzing the historical dataset. In this paper, we develop a general technique to capture discrimination based on the legally grounded situation testing methodology. For any individual, we find pairs of tuples from the dataset with similar characteristics apart from(More)
Anti-discrimination is an increasingly important task in data science. In this paper, we investigate the problem of discovering both direct and indirect discrimination from the historical data, and removing the discriminatory effects before the data is used for predictive analysis (e.g., building classifiers). We make use of the causal network to capture(More)
Discrimination discovery and prevention has received intensive attention recently. Discrimination generally refers to an unjustified distinction of individuals based on their membership, or perceived membership, in a certain group, and often occurs when the group is treated less favorably than others. However, existing discrimination discovery and(More)
Non-small cell lung cancer (NSCLC) is highly prevalent and needs novel therapies. Melanoma-associated antigen 3 (MAGE-A3) is a lung cancer antigen and calreticulin (CALR) can modulate immune responses. Our previous study has shown that up-regulated MAGE-A3 and CALR expression inhibits the proliferation and invasion of glioma cells. In this study, we(More)
Heat shock protein 90-beta (Hsp90-β) is associated with cell proliferation, differentiation and apoptosis and has been investigated as a prognostic factor in many cancers. However, Hsp90-β protein expression in lung adenocarcinoma (ADC) has not been thoroughly elucidated. The aim of this study was to determine the relationship between Hsp90-β expression,(More)
BACKGROUND It has been shown that 14-3-3 σ serves as a tumor suppressor gene, and is downregulated in various tumor tissues. However, the role of 14-3-3 σ during the initiation and progression of lung squamous cell carcinoma (SqCC) is not well understood. METHODS The expression status of 14-3-3 σ in archival tissue samples from 40 lung SqCC patients (36(More)
Cisplatin and its analogues are widely used as anti-tumor drugs in lung cancer but many cisplatin-resistant lung cancer cases have been identified in recent years. Single-stranded DNA-binding protein 1 (SSDBP1) can effectively induce H69 cell resistance to cisplatin in our previous identification; thus, it is necessary to explore the mechanism underlying(More)