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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Cell based therapies for ischemic stroke: From basic science to bedside
TLDR
This review attempts to provide a comprehensive synopsis of preclinical evidence and clinical experience of various donor cell types, their restorative mechanisms, delivery routes, imaging strategies, future prospects and challenges for translating cell therapies as a neurorestorative regimen in clinical applications. Expand
Intranasal ginsenoside Rb1 targets the brain and ameliorates cerebral ischemia/reperfusion injury in rats.
TLDR
This work suggests that intranasal GRb1 exerts brain-targeting effects and that a single dose of intran asalGRb1 immediately after MCAO ameliorates ischemia/reperfusion insult. Expand
Effects of repetitive transcranial magnetic stimulation on motor recovery and motor cortex excitability in patients with stroke: a randomized controlled trial
TLDR
This randomized, sham‐controlled, double‐blind study was to compare the effects of high‐frequency versus low‐frequency rTMS on motor recovery during the early phase of stroke and to identify the neurophysiological correlates of motor improvements. Expand
Intranasal nerve growth factor attenuates tau phosphorylation in brain after traumatic brain injury in rats
TLDR
It is demonstrated that intranasal NGF could effectively attenuate the hyperphosphorylation of tau after TBI, which might involve an integrated signaling pathway related to NF-κB. Expand
Effects of Brain-Derived Neurotrophic Factor on Local Inflammation in Experimental Stroke of Rat
TLDR
It is indicated that BDNF may modulate local inflammation in ischemic brain tissues on the cellular, cytokine, and transcription factor levels. Expand
Feasibility of Delivering Mesenchymal Stem Cells via Catheter to the Proximal End of the Lesion Artery in Patients with Stroke in the Territory of the Middle Cerebral Artery
TLDR
Intra-artery delivery of UCMSCs via catheterization was a feasible and safe approach and may improve the neurological function of ischemic stroke patients with the middle cerebral artery territory infarcts. Expand
An Optical Coherence Tomography Assessment of Stent Strut Apposition Based on the Presence of Lipid-Rich Plaque in the Carotid Artery
TLDR
Embedded stent struts, plaque prolapse, and fibrous cap rupture were more frequent and well-apposed stentstruts were less frequent after CAS in patients with lipid-rich plaque, which may be associated with acute stent thrombosis. Expand
Mesenchymal stem cells protect neurons against hypoxic-ischemic injury via inhibiting parthanatos, necroptosis, and apoptosis, but not autophagy
TLDR
MSCs potentially protect the cortical neurons from OGD-injury in vitro, through rescuing neurons from the cell death of parthanatos, necroptosis, and apoptosis, but not autophagy, which could provide some evidence to the mechanism explanation on stem cell treatment for ischemic stroke. Expand
MicroRNA-1906, a Novel Regulator of Toll-Like Receptor 4, Ameliorates Ischemic Injury after Experimental Stroke in Mice
TLDR
MiR-1906 is identified as a novel specific regulator of Toll-like receptor 4 (TLR4) and depicted its distinct expression patterns in different cerebral regions and cell types during ischemic attack, suggesting that the therapeutic supplementation of miR- 1906 can be beneficial in the modulation of poststroke inflammation. Expand
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