Learn More
Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide and the fourth most lethal cancer in China. However, although genomic studies have identified some mutations associated with ESCC, we know little of the mutational processes responsible. To identify genome-wide mutational signatures, we performed either whole-genome(More)
BACKGROUND Plasma based EGFR mutation analysis is emerging as a viable alternative to tumour tissue genotyping for patients with non-small cell lung carcinoma (NSCLC). The purpose of the study was to determine the degree of concordance between EGFR genotypes derived from matching tissue and blood samples. METHODS EGFR activating mutations L858R, exon 19(More)
OBJECTIVE To explore the relationship between C-reactive protein (CRP) and metabolic syndrome (MetS) in a rural Chinese population. DESIGN AND METHODS We performed a population-based cross-sectional study. RESULTS The median CRP was 0.90 mg/L. After exclusion of subjects with a CRP value >10 mg/L, The median CRP with 0, 1, 2, 3, 4, and 5 components of(More)
BACKGROUND We studied the association of C-reactive protein (CRP), gamma-glutamyltransferase (GGT) and type 2 diabetes in Chinese. METHOD A population-based cross-sectional study. RESULTS CRP and GGT levels were significantly higher in participants with diabetes than in those without (P<0.001). Higher CRP levels were positively associated with prevalent(More)
BACKGROUND & AIMS Heme oxygenase 1 (HO-1)-mediated increases in adiponectin, ameliorate the deleterious effects of obesity and metabolic syndrome; however, the effect of HO-1 on hepatic lipid metabolism remains elusive. The aim of this study is to evaluate the role of HO-1 in hepatic lipid metabolism. METHODS Functional studies were performed using(More)
The translocations of the anaplastic lymphoma kinase (ALK) gene with the echinoderm microtubule-associated protein-like 4 (EML4) gene on chromosome 2p have been identified in non-small-cell lung cancers (NSCLCs) as oncogenic driver mutations. It has been suggested that EML4-ALK fusion is associated with the resistance in NSCLCs to epidermal growth factor(More)
BACKGROUND EGFR mutation detection has been widely applied in the prediction of TKIs therapy in Non-Small Cell Lung Cancer (NSCLC). Metastatic tumors rather than primary tumors were usually assayed for those patients in advanced stages. Although the difference of EGFR mutation status in primary and metastatic tumors has been reported, the quantitative(More)
In order to solve the problems brought by the fixed parameters of the TCP Vegas, such as unfairness, an algorithm of TCP Adaptive Vegas based on the adaptive parameters is presented in this paper. The simulation results demonstrate that the new algorithm can adjust the parameters adaptively according to the conditions of network. Compared with algorithms of(More)
BACKGROUND AND OBJECTIVES The study aimed to compare the α fetoprotein (AFP), total β-human chorionic gonadotropin (hCG), and unconjugated estriol (uE3) levels in the second-trimester triple screening for Down syndrome with different regions, and to analyse the related factors that influenced the screening performance. MATERIALS AND METHODS The study was(More)
The impeller profile, which is one of the most important factors, determines the creation of shear stress which leads to blood hemolysis in the internal flow of centrifugal blood pump. The investigation of the internal flow field in centrifugal blood pump and the estimation of the hemolysis within different impeller profiles will provide information to(More)