Learn More
Protein arginine methyltransferases (PRMTs) plays critical roles in cancer. PRMT5 has been implicated in several types of tumors. However, the role of PRMT5 in cancer development remains to be fully elucidated. Here, we provide evidence that PRMT5 is overexpressed in colorectal cancer (CRC) cells and patient-derived primary tumors, correlated with increased(More)
To elucidate the molecular mechanisms involved in the therapeutic effects of proanthocyanidins from grape seeds (GSPE), we explore whether GSPE regulates the inflammatory response of TNBS-induced colitis in rats at the levels of NF-κB signal transduction pathway. Rats were intragastrically administered of different doses of GSPE (100, 200 and 400 mg·kg-1)(More)
Protein arginine methyltransferase 5 (PRMT5), a type II PRMT, is highly expressed in some tumors, but its role in hepatocellular carcinoma (HCC) is still unknown. PRMT5 level in HCC specimens was determined by immunohistochemical staining and the association with clinicopathologic features was evaluated. PRMT5 was inhibited by AMI-1 (a small molecule(More)
This study examines the relative importance of six variables: area, the mid-domain effect, temperature, precipitation, productivity, and habitat heterogeneity on elevational patterns of species richness for breeding birds along a central Himalaya gradient in the Gyirong Valley, the longest of five canyons in the Mount Qomolangma National Nature Reserve. We(More)
Service Supply Chain (SSC) have seen considerable attention in the business circles and academia. However, little focused on Service Integrator (SI), especially the research results about SI competitiveness and its influencing factors in the context of SSC has not yet appeared. This paper study the formation mechanism of Service Integrator competitiveness(More)
Interspecific foraging associations are well-documented phenomena, characterized by one or more species exploiting the behavior of another species to decrease predation or increase foraging success. In rare cases, birds directly exploit human behavior, but examples of these interactions are limited to species that naturally occur in edge, open, or disturbed(More)
  • 1