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Demethylation of CpG islands in the 5' upstream regions mediates the expression of the human testis-specific gene MAGEB16 and its mouse homolog Mageb16
The human MAGEB16 gene and its mouse homolog, Mageb16, are only expressed in the testis and the expression of these genes could be activated by treatment with the demethylation agent 5'-aza-2'-deoxycytidine (5-aza-CdR).
Testis‐specific protein, Y‐linked 1 activates PI3K/AKT and RAS signaling pathways through suppressing IGFBP3 expression during tumor progression
The testis‐specific protein, Y‐linked 1 (TSPY1), a newly recognized cancer/testis antigen, has been suggested to accelerate tumor progression. However, the mechanisms underlying TSPY1 cancer‐related
Novel compound heterozygous mutations of ALDH1A3 contribute to anophthalmia in a non-consanguineous Chinese family
Those heterozygous mutations in ALDH1A3 should be considered for molecular screening in anophthalmia, particularly in cases from families without consanguineous relationships.
Epigenetic modifications promote the expression of the orphan nuclear receptor NR0B1 in human lung adenocarcinoma cells
It is shown that CpG methylation within the NR0B1 promoter is not involved in the in vivo regulation of NR 0B1 expression, whereas the hyperacetylation of histone H4 and the unmethylation of Histones H3K9 and H3 k27 results in decondensed euchromatin for NR0 B1 activation.
Targeted disruption of the mouse testis-enriched gene Znf230 does not affect spermatogenesis or fertility
It is suggested that Znf230 deficiency in mice may not affect growth, fertility or spermatogenesis.
DNA demethylation facilitates the specific transcription of the mouse X-linked Tsga8 gene in round spermatids†.
The details of a regulatory mechanism that includes DNA methylation and transcription factors to mediate the postmeiotic expression of an X-linked gene are reported.
[Progress in epigenetic research on male infertility].
Recent progress made in research on epigenetic regulation including DNA methylation, histone modification and non-coding RNA related with male infertility are reviewed.
Monitoring cancer progression by detecting circulating cancer cells with both epithelial and mesenchymal features
A novel CTC detection and genomic analysis approach is developed, which can efficiently analyse both CK+ and CK-/vimentin+/CD45cancer CTCs, and greatly enhances the ability to investigate cancer metastasis process and using C TCs to monitor cancer progression and therapeutic response.
Transcription factor Sp1 is necessary and functional in regulating expression of oncogene ZNF703
The data suggest that ZNF703 transcription is regulated by transcription factor Sp1, which should facilitate future studies of the mechanism which regulates expression of this important gene.