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Hsa-miR-599 suppresses the migration and invasion by targeting BRD4 in breast cancer
TLDR
The results suggest that hsa-miR-599 serves as an oncosuppressive microRNA that impairs breast cancer tumorigenesis and progression by directly targeting BRD4. Expand
Gambogic acid increases the sensitivity to paclitaxel in drug-resistant triple-negative breast cancer via the SHH signaling pathway
TLDR
The combination of GA with pac litaxel may increase the antitumor effects on paclitaxel-resistant TNBC via downregulating the SHH signaling pathway. Expand
Role of N-Cadherin in a Niche-Mimicking Microenvironment for Chondrogenesis of Mesenchymal Stem Cells In Vitro.
TLDR
It is demonstrated that N-cadherin plays the critical role in early mesenchymal condensation, and the collagen hydrogel provides a supportive microenvironment for late chondrogenic differentiation. Expand
Long non‑coding RNA UCA1 promotes papillary thyroid cancer cell proliferation via miR‑204‑mediated BRD4 activation.
TLDR
UCA1 may be regarded as an oncogenic lncRNA, promoting PTC cell proliferation, and be a potential target for human PTC treatment, as well as a competing endogenous RNA by sponging miR‑204. Expand
Long noncoding RNA UCA1 promotes anaplastic thyroid cancer cell proliferation via miR‑135a‑mediated c‑myc activation.
TLDR
UCA1 served as an oncogenic long non‑coding RNA promoting ATC cell proliferation and may be a potential target for human ATC treatment. Expand
Epigallocatechin-3-gallate Protects against Hydrogen Peroxide-Induced Inhibition of Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells
TLDR
The results suggested that EGCG can reduce the effects of oxidative stress on Wnt pathway in osteogenic cells, which supported a potentially promising therapy of bone disorders induced by oxidative stress. Expand
The Long Non-Coding RNA MALAT1 Enhances Ovarian Cancer Cell Stemness by Inhibiting YAP Translocation from Nucleus to Cytoplasm
TLDR
A MALAT1/YAP axis responsible for ovarian cancer cell stemness is demonstrated, demonstrated as the decrease of sphere forming ability, expression of stemness regulatory masters, and attenuation of cisplatin resistance. Expand
LARP7 in papillary thyroid carcinoma induces NIS expression through suppression of the SHH signaling pathway
TLDR
LARP7 may act as a tumor suppressor in PTC by inhibiting the SHH signaling pathway and may be a promising therapeutic target in patients with PTC. Expand
Bromodomain-containing protein 4 is critical for the antiproliferative and pro-apoptotic effects of gambogic acid in anaplastic thyroid cancer
TLDR
It was demonstrated that GA decreased the expression of bromodomain-containing protein 4 (BRD4), which has been reported to function as an oncogene in various types of cancer, which suggested that GA served its anticancer functions partially via downregulating BRD4. Expand
Bionic cartilage acellular matrix microspheres as a scaffold for engineering cartilage.
TLDR
The advantages of micron-sized BCAMMs are outlined, specifically in the easier decellularization process without grinding, homogeneous cell seeding and infiltration, chondrogenic induction and better fitting to the irregular lesion shape. Expand
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