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Systems approaches and polypharmacology for drug discovery from herbal medicines: an example using licorice.
A Systems Biology Approach to Understanding the Mechanisms of Action of Chinese Herbs for Treatment of Cardiovascular Disease
The action mechanism of these three important Chinese herbs for the treatment of CVD is uncovered, by generating and identifying both their active ingredients and novel targets specifically related to CVD, which clarifies some of the common conceptions in TCM, and thus provides clues to modernize such specific herbal medicines.
Systematic understanding the mechanisms of vitiligo pathogenesis and its treatment by Qubaibabuqi formula.
Systems pharmacology to decipher the combinational anti-migraine effects of Tianshu formula.
CancerHSP: anticancer herbs database of systems pharmacology
An anticancers herbs database of systems pharmacology (CancerHSP), which records anticancer herbs related information through manual curation, will help reveal the molecular mechanisms of natural anticancer products and accelerate anticancer drug development, especially facilitate future investigations on drug repositioning and drug discovery.
A novel systems pharmacology platform to dissect action mechanisms of traditional Chinese medicines for bovine viral diarrhea disease.
Systems pharmacology-based approach for dissecting the addition and subtraction theory of traditional Chinese medicine: An example using Xiao-Chaihu-Decoction and Da-Chaihu-Decoction
Systems Pharmacology in Small Molecular Drug Discovery
- W. Zhou, Yonghua Wang, A. Lu, Ge Zhang
- Biology, MedicineInternational journal of molecular sciences
- 1 February 2016
This review is an attempt to introduce how holistic systems pharmacology that integrated in silico ADME/T (i.e., absorption, distribution, metabolism, excretion and toxicity), target fishing and network pharmacology facilitates the discovery of small molecular drugs at the system level.
Deciphering the combination principles of Traditional Chinese Medicine from a systems pharmacology perspective based on Ma-huang Decoction.
Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine
An integrated systems pharmacology approach is presented for illustrating the molecular correlations between CVDs and GIDs and suggests a novel integrated strategy for rational drug development for complex associated diseases.