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A new method for PID controller tuning based on process models for cascaded control systems is proposed in this paper. The method consists of first finding the ideal controller that gives the desired closed loop response and then finding the PID approximation of the ideal controller by Maclaurin series. This method can be applied to any open loop stable(More)
BACKGROUND Glucagon-like peptide-1 (GLP-1) is a gut-derived incretin hormone that plays an important role in glucose homeostasis. Its functions include glucose-stimulated insulin secretion, suppression of glucagon secretion, deceleration of gastric emptying, and reduction in appetite and food intake. Despite the numerous antidiabetic properties of GLP-1,(More)
BACKGROUND Previous studies demonstrating the efficacy of insulin gene therapy have mostly involved use of adenoviral vectors or naked DNA to deliver the insulin gene. However, this procedure may not guarantee long-term insulin production. To improve the performance, we prepared recombinant adeno-associated viral vectors (rAAV) harboring the gene encoding a(More)
Within any organization (e.g. a hospital or clinic) the perception of the way things operate may vary dramatically as a function of one's location in the organizational hierarchy as well as one's professional discipline. Interorganizational variability depends on organizational coherence, safety, and stability. In this four-nation (Canada, Ireland,(More)
Proportional, integral, and deriuatiue (PID) parameters are obtained for general process models by approximating the feedback form of an IMC controller with a Maclaurin series in the Laplace uariable. These PID parameters yield closed-loop responses that are closer to the desired responses than those obtained by PID controllers tuned by other methods. The(More)
Very long instruction word processors (VLIW) allow to execute multiple instructions in parallel. At the same time VLIW compilers optimize the source code for maximum performance by grouping as many instructions in parallel as possible. This work addresses the problem of thermal- awareness in VLIW compilers with a temperature control and reduction techniques(More)
Lithospermic acid B (LAB) has been reported to protect OLETF rats, an established type 2 diabetic animal model, from the development of diabetes-related vascular complications. We investigated whether magnesium lithospermate B (LAB) has a protective role under cytokine-induced apoptosis in INS-1 cells in vitro and whether it slows the development of(More)
AIMS We have investigated the effects of magnesium lithospermate B (MLB), the active compound of the Oriental herbal remedy, Salvia miltiorrhizae, on endothelial dysfunction associated with diabetes mellitus using cultured endothelial cells and an animal model of type 2 diabetes mellitus. METHODS AND RESULTS The effect of MLB on vasodilatory function in(More)
As the technology scales, the increase of circuit delay over time due to NBTI (negative bias temperature instability) effect is not negligible any more. It has been known that voltage scaling is an effective scheme that is able to mitigate the NBTI effect. However, a careful control of voltage scaling is required not to increase the dissipation of dynamic(More)