Yonghao Zhao

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β-site APP cleaving enzyme 1 (BACE1) cleaves β-amyloid precursor protein (APP) to initiate the production of β-amyloid (Aβ), the prime culprit in Alzheimer’s disease (AD). Dysregulation of the intracellular trafficking of BACE1 may affect Aβ generation, contributing to AD pathology. In this study, we investigated whether BACE1 trafficking and BACE1-mediated(More)
The superior mechanical properties of carbon nanotubes (CNTs) mean they have been regarded as a new material with the potential to revolutionize and enable many advanced technologies. CNTs have extremely high tensile strength ( 150 GPa), high modulus ( 1 TPa), large aspect ratio, low density, good chemical and environmental stability, and high thermal and(More)
Carbon nanotubes (CNTs) are the strongest materials ever discovered by mankind. With measured tensile strengths as high as 150 GPa and a high modulus of 1 TPa, CNTs are very promising for many high-strength, lightweight applications. Several approaches have been reported to process micrometer-long CNTs into fibers, including dispersing CNTs into polymer or(More)
Colistin is a cyclic cationic polypeptide antibiotic with activity against multidrug-resistant Gram-negative bacteria. Our recent study demonstrated that colistin induces apoptosis in primary chick cortex neurons and PC-12 cells. Although apoptosis and autophagy have different impacts on cell fate, there is a complex interaction between them. Autophagy(More)
Increasing the strength of metallic alloys while maintaining formability is an interesting challenge for enabling new generations of lightweight structures and technologies. In this paper, we engineer aluminium alloys to contain a hierarchy of nanostructures and possess mechanical properties that expand known performance boundaries-an aerospace-grade 7075(More)
From the stone ages to modern history, new materials have often been the enablers of revolutionary technologies. For a wide variety of envisioned applications in space exploration, energy-efficient aircraft, and armor, materials must be significantly stronger, stiffer, and lighter than what is currently available. Carbon nanotubes (CNTs) have extremely high(More)
Spun carbon nanotube (CNT) fibers have great potential for conducting and sensing applications owing to their unique, tunable electrical properties. Here we report the electron transport properties of neat, well-aligned CNT fibers spun from arrays of millimeter-long CNTs. The conductivity of asspun CNT fibers is around 595.2 S cm at room temperature, and(More)
High strength, low Young's modulus and good biocompatibility are desirable but difficult to simultaneously achieve in metallic implant materials for load bearing applications, and these impose significant challenges in material design. Here we report that a nano-grained β-Ti alloy prepared by high-pressure torsion exhibits remarkable mechanical and(More)
Theoretical modeling suggests that the grain size remains unchanged during fatigue crack growth in nanocrystalline metals. Here we demonstrate that a modulated structure is generated in a nanocrystalline Ni-Fe alloy under cyclic deformation. Substantial grain coarsening and loss of growth twins are observed in the path of fatigue cracks, while the grains(More)
In this study, a kind of Al-TiB₂/TiC in situ composite was successfully prepared using the melt reaction method and the accumulative roll-bonding (ARB) technique. The microstructure evolution of the composites with different deformation treatments was characterized using field emission scanning electron microscopy (FESEM) and a transmission electron(More)