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β-site APP cleaving enzyme 1 (BACE1) cleaves β-amyloid precursor protein (APP) to initiate the production of β-amyloid (Aβ), the prime culprit in Alzheimer’s disease (AD). Dysregulation of the intracellular trafficking of BACE1 may affect Aβ generation, contributing to AD pathology. In this study, we investigated whether BACE1 trafficking and BACE1-mediated(More)
Colistin is a cyclic cationic polypeptide antibiotic with activity against multidrug-resistant Gram-negative bacteria. Our recent study demonstrated that colistin induces apoptosis in primary chick cortex neurons and PC-12 cells. Although apoptosis and autophagy have different impacts on cell fate, there is a complex interaction between them. Autophagy(More)
Increasing the strength of metallic alloys while maintaining formability is an interesting challenge for enabling new generations of lightweight structures and technologies. In this paper, we engineer aluminium alloys to contain a hierarchy of nanostructures and possess mechanical properties that expand known performance boundaries-an aerospace-grade 7075(More)
Resonant laser scattering along with photon correlation measurements established the atom-like character of quantum dots. Here, we show that for a wide range of experimental parameters it is impossible to isolate elementary quantum-dot excitations from a strong influence of nuclear spins; the absorption lineshapes at magnetic fields exceeding 1 T indicate(More)
From the stone ages to modern history, new materials have often been the enablers of revolutionary technologies. [1] For a wide variety of envisioned applications in space exploration, energy-efficient aircraft, and armor, materials must be significantly stronger, stiffer, and lighter than what is currently available. Carbon nanotubes (CNTs) have extremely(More)
Carbon nanotubes (CNTs) are the strongest materials ever discovered by mankind. With measured tensile strengths as high as 150 GPa and a high modulus of 1 TPa, [1,2] CNTs are very promising for many high-strength, lightweight applications. [3,4] Several approaches have been reported to process micrometer-long CNTs into fibers, including dispersing CNTs into(More)
Spun carbon nanotube (CNT) fibers have great potential for conducting and sensing applications owing to their unique, tunable electrical properties. [1–5] Here we report the electron transport properties of neat, well-aligned CNT fibers spun from arrays of millimeter-long CNTs. The conductivity of as-spun CNT fibers is around 595.2 S cm –1 at room(More)
Reliable preparation, manipulation and measurement protocols are necessary to exploit a physical system as a quantum bit. Spins in optically active quantum dots offer one potential realization and recent demonstrations have shown high-fidelity preparation and ultrafast coherent manipulation. The final challenge-that is, single-shot measurement of the(More)
We propose and demonstrate an all-optical approach to single-electron sensing using the optical transitions of a semiconductor quantum dot. The measured electric-field sensitivity of 5 (V/m)/√Hz corresponds to detecting a single electron located 5 μm from the quantum dot-nearly 10 times greater than the diffraction limited spot size of the excitation(More)