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β-site APP cleaving enzyme 1 (BACE1) cleaves β-amyloid precursor protein (APP) to initiate the production of β-amyloid (Aβ), the prime culprit in Alzheimer’s disease (AD). Dysregulation of the intracellular trafficking of BACE1 may affect Aβ generation, contributing to AD pathology. In this study, we investigated whether BACE1 trafficking and BACE1-mediated(More)
Increasing the strength of metallic alloys while maintaining formability is an interesting challenge for enabling new generations of lightweight structures and technologies. In this paper, we engineer aluminium alloys to contain a hierarchy of nanostructures and possess mechanical properties that expand known performance boundaries-an aerospace-grade 7075(More)
From the stone ages to modern history, new materials have often been the enablers of revolutionary technologies. [1] For a wide variety of envisioned applications in space exploration, energy-efficient aircraft, and armor, materials must be significantly stronger, stiffer, and lighter than what is currently available. Carbon nanotubes (CNTs) have extremely(More)
Carbon nanotubes (CNTs) are the strongest materials ever discovered by mankind. With measured tensile strengths as high as 150 GPa and a high modulus of 1 TPa, [1,2] CNTs are very promising for many high-strength, lightweight applications. [3,4] Several approaches have been reported to process micrometer-long CNTs into fibers, including dispersing CNTs into(More)
Spun carbon nanotube (CNT) fibers have great potential for conducting and sensing applications owing to their unique, tunable electrical properties. [1–5] Here we report the electron transport properties of neat, well-aligned CNT fibers spun from arrays of millimeter-long CNTs. The conductivity of as-spun CNT fibers is around 595.2 S cm –1 at room(More)
Defects are almost inevitable during the fabrication process, and their existence strongly affects thermodynamic and (opto)electronic properties of two-dimensional materials. Very recent experiments have provided clear evidence for the presence of larger multi-vacancies in silicene, but their structure, stability, and formation mechanism remain largely(More)
Nanostructured (NS) and ultrafine-grained (UFG) materials have high strength and relatively low ductility. Their toughness has not been comprehensively investigated. Here we report the Charpy impact behavior and the corresponding microstructural evolutions in UFG Cu with equi-axed and elongated grains which were prepared by equal channel angular pressing(More)
In this study, a kind of Al-TiB 2 /TiC in situ composite was successfully prepared using the melt reaction method and the accumulative roll-bonding (ARB) technique. The microstructure evolution of the composites with different deformation treatments was characterized using field emission scanning electron microscopy (FESEM) and a transmission electron(More)
Scanning electron microscopy transmission Kikuchi diffraction is able to identify twins in nanocrystalline material, regardless of their crystallographic orientation. In this study, it was employed to characterize deformation twins in Cu/10 wt % Zn processed by high-pressure torsion. It was found that in 83% of grains containing twins, at least one twin(More)
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