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Advances in saponin-based adjuvants.
This review will summarize the current advances concerning adjuvant effects of different kinds of saponins and the structure-activity relationship of sap onin adjuvants will also be discussed in the light of recent findings. Expand
ISCOMs and ISCOMATRIX.
ISCOMs and ISCOMATRIX vaccines have now been shown to induce strong antigen-specific cellular or humoral immune responses to a broad range of antigens of viral, bacterial, parasite origin or tumor in a number of animal species including non-human primates and humans. Expand
Comparative antimicrobial activity and mechanism of action of bovine lactoferricin-derived synthetic peptides
Synthetic LfcinB had a major permeability effect on the cytoplasmic membrane of both Gram-positive and Gram-negative bacteria, which also indicated it may be a possible intracellular target. Expand
Expressing antimicrobial peptide cathelicidin-BF in Bacillus subtilis using SUMO technology
- C. Luan, H. Zhang, Deguang Song, Yonggang Xie, Jie Feng, Y. Wang
- Biology, Medicine
- Applied Microbiology and Biotechnology
- 1 April 2014
This is the first report of the production of an endotoxin-free antimicrobial peptide, CBF, by recombinant DNA technology, as well as the first time purified SUMO protease 1 with high activity has been produced from B. subtilis. Expand
Platycodin D is a potent adjuvant of specific cellular and humoral immune responses against recombinant hepatitis B antigen.
PD has strong potential to increase both cellular and humoral immune responses and elicit a balanced Th1/Th2 response against HBsAg, and that PD may be the candidates as adjuvants for use in prophylactic and therapeutic hepatitis B vaccine. Expand
Contribution of the glycidic moieties to the haemolytic and adjuvant activity of platycodigenin-type saponins from the root of Platycodon grandiflorum.
The results suggested that the number of sugar residues in the glycidic chains attached to C-3 of aglycone could affect the haemolytic and adjuvant activities of platycodigenin-type saponins, and that PD had immunological adjUvant activity, and simultaneously elicited a Th1 and Th2 immune response by regulating gene expression of Th1/Th2 cytokines and transcription factors. Expand
Platycodin D Improves the Immunogenicity of Newcastle Disease Virus‐Based Recombinant Avian Influenza Vaccine in Mice
1 could improve the immunogenicity of the rL‐H5 vaccine by enhancing both humoral and cellular immune responses in mice, and that 1 is a promising adjuvant for influenza vaccines is concluded. Expand
Antimicrobial peptides derived from different animals: comparative studies of antimicrobial properties, cytotoxicity and mechanism of action
Evaluating the therapeutic potential of six antimicrobial peptides initially found from animals indicated that cecropin P1 possessed the most desired biological activity, with fast and potent antimicrobial activity but only slight hemolytic or cytotoxic activity against human cells. Expand
Effects of thioredoxin: SUMO and intein on soluble fusion expression of an antimicrobial peptide OG2 in Escherichia coli.
- Yonggang Xie, C. Luan, +5 authors Yi-zhen Wang
- Biology, Medicine
- Protein and peptide letters
- 31 December 2012
This study investigated three fusion partners, including thioredoxin, Mxe GyrA intein, and small ubiquitin-like modifier (SUMO), each fused with OG2, and examined their effects on the expression level and solubility of OG2 in Escherichia coli. Expand
A promising balanced Th1 and Th2 directing immunological adjuvant, saponins from the root of Platycodon grandiflorum.
PGS seem to be a promising balanced Th1 and Th2 directing immunological adjuvants which can enhance the immunogenicity of vaccine. Expand