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3,5,6-Trichloro-2-pyridinol (TCP) is a primary degradation product of chlorpyrifos and chlorpyrifos-methyl. TCP has longer half-life in soil and greater solubility in water than its parent compound, and cause wide contamination in environments. However, studies about the toxic effects of TCP are limited and outdate. In this study, 5 mg/kg/day, 50 mg/kg/day,(More)
Mixed chemical wastewaters (MCWW) from industrial park contain complex mixtures of trace contaminants, which cannot be effectively removed by wastewater treatment plants (WWTP) and have become an unignored threat to ambient environment. However, limited information is available to evaluate the complicated toxic effects of MCWW and its effluent from(More)
Microplastics have become emerging contaminants, causing widespread concern about their potential toxic effects. In this study, the uptake and tissue accumulation of polystyrene microplastics (PS-MPs) in zebrafish were detected, and the toxic effects in liver were investigated. The results showed that after 7 days of exposure, 5 μm diameter MPs accumulated(More)
Disinfection byproducts (DBPs) in drinking water have been linked to various diseases, including colon, colorectal, rectal, and bladder cancer. Trichloroacetamide (TCAcAm) is an emerging nitrogenous DBP, and our previous study found that TCAcAm could induce some changes associated with host-gut microbiota co-metabolism. In this study, we used an integrated(More)
Haloacetamides (HAcAms) as a new class of nitrogenous disinfection byproducts (N-DBPs) have been widely detected in drinking water and reclaimed water. Cytotoxicity and genotoxicity of monoHAcAms are determined by the leaving tendency of the halogens and decrease following a rank order of iodoacetamide (IAcAm)>bromoacetamide (BAcAm)≫chloroacetamide (CAcAm).(More)
Municipal wastewater effluents (MWWE) contain a lot of trace organic pollutants, which will be a threat to environmental health. However, little information is available for the mixed toxicity of MWWE on mammals. In the present study, male mice were exposed to MWWE for 90 days, and then, histopathology and clinical biochemistry determination and(More)
This paper constructs a parameter inverse analysis model for the diffusion analysis experiments of multi-ion transport model. It transforms multi-parameter inverse analysis problem into an optimization problem for nonlinear constrained planning. The optimization principle, the sequential quadratic programming method (SQP) for optimization and its(More)
Bromoacetonitriles (BANs), one class of nitrogenous disinfection byproducts (N-DBPs), have frequently been detected in drinking water. The cytotoxicity and genotoxicity of BANs have been demonstrated in mammalian cells. However, a systematic study of the in vivo toxicity of BANs is rare. In this study, metabolomics combined with histopathology and oxidative(More)
Microplastics (MPs) are a significant environmental health issue and increasingly greater source of concern. MPs have been detected in oceans, rivers, sediments, sewages, soil and even table salts. MPs exposure on marine organisms and humans has been documented, but information about the toxicity of MPs in mammal is limited. Here we used fluorescent and(More)