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Subcellular Fractionation-SH-SY5Y/APP695myc cells were harvested and homogenized in cell lysis buffer containing 50 mM Tris-HCl (pH 7.4), 150 mM NaCl, 1 mM EDTA, 0.25 mM PMSF and cocktails of protease inhibitors. The homogenate was centrifuged for 10 min at 1,000×g at 4°C to prepare a post-nuclear supernatant fraction. Membranes were pelleted from the PNS(More)
BACKGROUND AND OBJECTIVE To prospectively investigate the relationship between the apparent diffusion coefficient (ADC) and cellularity in lung cancer. METHODS Sixty patients histopathologically confirmed with lung cancer (41 men, 19 women) underwent diffusion-weighted magnetic resonance imaging of the chest (with b values of 50 and 1000 s/mm2). The(More)
Human fibroblast-like synoviocytes play a vital role in joint synovial inflammation in rheumatoid arthritis (RA). Proinflammatory cytokines induce fibroblast-like synoviocyte activation and dysfunction. The inflammatory mediator Krüppel-like factor 4 is upregulated during inflammation and plays an important role in endothelial and macrophage activation(More)
BACKGROUND/OBJECTIVES To prospectively examine the relation between tumor vascularity and glucose metabolism in adenocarcinoma (AC) and squamous cell carcinoma(SCC) of the lung by using positron emission tomography/computed tomography (PET/CT) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). MATERIALS AND METHODS Forty-one consecutive(More)
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