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BACKGROUND L-Threonine is an important amino acid for animal feed. Though the industrial fermentation technology of threonine achieved a very high level, there is still significant room to further improve the industrial strains. The biosensor-based high-throughput screening (HTS) technology has demonstrated its powerful applications. Unfortunately, for most(More)
BACKGROUND The overexpression of key enzymes in a metabolic pathway is a frequently used genetic engineering strategy for strain improvement. Metabolic control analysis has been proposed to quantitatively determine key enzymes. However, the lack of quality data often makes it difficult to correctly identify key enzymes through control analysis. Here, we(More)
L-Phenylalanine (L-Phe) is an important amino acid used in both food and medicinal applications. We developed an in vitro system that allowed a direct, quantitative investigation of phenylalanine biosynthesis in E. coli. Here, the absolute concentrations of six enzymes (AroK, AroL, AroA, AroC, PheA and TyrB) involved in the shikimate (SHIK) pathway were(More)
Cytidine is an industrially useful precursor for the production of antiviral compounds and a variety of industrial compounds. Interest in the microbial production of cytidine has grown recently and high-throughput screening of cytidine over-producers is an important approach in large-scale industrial production using microorganisms. An enzymatic assay for(More)
Graphic processing units (GPUs) is widely used to accelerate the processing speed of the radar detection procedure, including the range compression, coherent integration and constant false alarm rate. Specifically, detailed parallel design of the radar algorithm and the thread programming are shown. The experimental results show that, by engaging the(More)
According to the monitoring of the wide area measurement system, inter-area oscillations happen more and more frequently in a real power grid of China, which are close to the forced oscillation. Applying the conventional forced oscillation theory, the mechanism of these oscillations cannot be explained well, because the oscillations vary with random(More)
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