Yongfei Chen

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Wenchao Wang1
James D. Griffin1
Steven P. Treon1
Sara J. Buhrlage1
1Wenchao Wang
1James D. Griffin
1Steven P. Treon
1Sara J. Buhrlage
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BTK is a member of the TEC family of non-receptor tyrosine kinases whose deregulation has been implicated in a variety of B-cell-related diseases. We have used structure-based drug design in conjunction with kinome profiling and cellular assays to develop a potent, selective, and irreversible BTK kinase inhibitor, QL47, which covalently modifies Cys481.(More)
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