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Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.
TLDR
Resveratrol sulfates displayed low antiproliferative activity and negligible uptake in MCF7 cells, and its 3'-sulfate and 4-sulfates inhibit NO production by NO scavenging and down-regulation of iNOS expression in RAW 264.7 cells. Expand
Pivotal Role of Reactive Oxygen Species in Differential Regulation of Lipopolysaccharide-Induced Prostaglandins Production in Macrophages
TLDR
Results show that LPS-induced NOX-generated ROS production differentially and specifically regulates the H-PGDS-mediated production of PGD2, but not PGE2, in mouse BMDM. Expand
Lipopolysaccharide-Induced Expression of Microsomal Prostaglandin E Synthase-1 Mediates Late-Phase PGE2 Production in Bone Marrow Derived Macrophages
TLDR
The data show that mPGES-1, but not m PGES-2 or c-PGES isomerase, mediates LPS-induced late-phase burst of PGE2 generation, and regulates L PS-induced iNOS expression in BMDM. Expand
TUG1 mediates methotrexate resistance in colorectal cancer via miR-186/CPEB2 axis.
TLDR
This study suggests that lncRNA TUG1 mediates MTX resistance in colorectal cancer via miR-186/CPEB2 axis. Expand
Repair of injured spinal cord using biomaterial scaffolds and stem cells
TLDR
An optimal multi‒disciplinary approach of combining biomaterials, stem cells, and biomolecules offers a promising treatment for the injured spinal cord. Expand
Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation.
TLDR
Subsegmental bronchoprovocation with allergen in patients with mild asthma resulted in a remarkable increase in bronchoalveolar lavage fluid levels of LPA enriched in polyunsaturated 22:5 and 22:6 fatty acids in association with increased concentrations of ATX protein. Expand
Collagen microsphere serving as a cell carrier supports oligodendrocyte progenitor cell growth and differentiation for neurite myelination in vitro
TLDR
The viability of oligodendrocyte progenitor cells, B104 cells and PC12 cells grown on microspheres was not significantly different with those in cell culture plates, demonstrating the feasibility of collagenmicrospheres in further applications for the delivery of neural progenitors cells for neural regeneration. Expand
Transarterial sorafenib chemoembolization: preliminary study of technical feasibility in a rabbit model.
TLDR
Targeted transarterial sorafenib delivery is feasible and results in higher tissue drug levels than reported for systemic sorAFenib therapy, without immediate histopathologic tissue toxicity. Expand
Exploration of molecular pathways mediating electric field‐directed schwann cell migration by RNA‐seq
TLDR
It is reported that Schwann cells migrate anodally in an applied electric field (EF) and the directedness and displacement of anodal migration increased significantly when the strength of the EF increased from 50’mV/mm to 200 mV /mm, and the EF did not significantly affect the cell migration speed. Expand
Cordycepin inhibits LPS‐induced acute lung injury by inhibiting inflammation and oxidative stress
TLDR
It is demonstrated that cordycepin could attenuate LPS‐induced ALI effectively, probably due to inhibition of inflammation and oxidative stress. Expand
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