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Vasorelaxant and antihypertensive effects of formononetin through endothelium-dependent and -independent mechanisms
In spontaneously hypertensive rats, formononetin slowly lowered the systolic, diastolic and mean arterial pressure, probably due to inhibition of voltage-dependent Ca2+ channels and intracellular Ca2-free depolarized medium and by releasing NO.
Antihypertensive effect of formononetin through regulating the expressions of eNOS, 5-HT2A/1B receptors and α1-adrenoceptors in spontaneously rat arteries.
Formononetin upregulates nitric oxide synthase in arterial endothelium through estrogen receptors and MAPK pathways
- Tao Sun, Lei Cao, Na-na Ping, Yuehua Wu, Dong-zheng Liu, Yong-xiao Cao
- BiologyThe Journal of pharmacy and pharmacology
- 1 March 2016
This study investigated the hypothesis that formononetin upregulates eNOS through estrogen receptors and MAPK pathways to improve arterial endothelial cell function.
Imperatorin induces vasodilatation possibly via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release.
Ligustilide induces vasodilatation via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release.
Lipid-soluble smoke particles damage endothelial cells and reduce endothelium-dependent dilatation in rat and man
- Jin-Yan Zhang, Yong-xiao Cao, Cang-bao Xu, L. Edvinsson
- Medicine, BiologyBMC cardiovascular disorders
- 19 January 2006
It is demonstrated that the lipid-soluble smoke particles, but not nicotine, caused damage to arterial endothelium and reduced the endothelia-dependent dilatation in man and rat.
DMSO-Soluble Cigarette Smoke Particles Alter the Expression of Endothelin B Receptor in Rat Coronary Artery
- Lin-hong Huang, Ping Zhang, Jian-yu He, Jing Liu, Yong-xiao Cao
- Biology, ChemistryJournal of Vascular Research
- 22 May 2013
The results indicate that DSP upregulates ETB receptors in rat coronary artery via ERK1/2 and the NF-κB pathway.
Comprehensive comparison of therapeutic efficacy of radiofrequency target disc decompression and nucleoplasty for lumbar disc herniation: a five year follow-up
- Hui-yong Nie, Ya-bin Qi, Na Li, Suo-liang Wang, Yong-xiao Cao
- MedicineInternational Orthopaedics
- 1 April 2018
Both TDD and nucleoplasty can reduce pain in patients with lumbar disc herniation and improve quality of life and operation time affects the treatment effect.
Estimating the instant case fatality rate of COVID-19 in China
Cigarette Smoke Upregulates Rat Coronary Artery Endothelin Receptors In Vivo
- Lei Cao, Yaping Zhang, Yong-xiao Cao, L. Edvinsson, Cang-bao Xu
- Biology, MedicinePLoS ONE
- 7 March 2012
The protein levels of phosphorylated (p)-Raf-1 and p-ERK1/2 in smoke exposed rats were significantly higher than in control rats, demonstrating that SHS induces the activation of the Raf/ERK/MAPK pathway.