Yong-xian Zhang

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Precision medicine emerges as a new approach that takes into account individual variability. The successful conduct of precision medicine requires the use of precise disease models. Human pluripotent stem cells (hPSCs), as well as adult stem cells, can be differentiated into a variety of human somatic cell types that can be used for research and drug(More)
The RNA-guided CRISPR (clustered regularly interspaced short palindromic repeat)-associated Cas9 nuclease has offered a new platform for genome editing with high efficiency. Here, we report the use of CRISPR/Cas9 technology to target a specific genomic region in human pluripotent stem cells. We show that CRISPR/Cas9 can be used to disrupt a gene by(More)
HUANG Yu-jie, the famous TCM physician of Taiwan in the late Qing dynasty and early Republican period of China, was a physician with noble medical morality and perfect medical skill. He made distinguished contributions especially to the prevention and treatment of epidemic disease. During the time he undertook the medical work, he also actively took part in(More)
Model set design method has been one of the focuses of the research on multi-model control. The immune system is a excellent biological multi-model control system. In the immune system, the antibody is the model of antigen. Many kinds of antibodies constitute the idiotypic network. This network can be regarded as the model set of antigens. Among these(More)
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