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Caesalminaxins A-L, cassane diterpenoids from the seeds of Caesalpinia minax.
Fourteen new cassane diterpenoids, caesalminaxins A-L (1-14), and three known compounds were isolated from the seeds of Caesalpinia minax, and compounds 3 and 4 possess a rare spiro C/D ring system.
Guanidine alkaloids from Plumbago zeylanica.
Eleven new guanidine alkaloids, plumbagines A-G and plumbagosides A-D (9-12), as well as two known analogues (1, 13), were isolated from the aerial parts of Plumbago zeylanica by spectroscopic analyses.
Identification of Cyclic Depsipeptides and Their Dedicated Synthetase from Hapsidospora irregularis.
A comparison of the structures of leualacin and its analogues indicated that the A2 and A4 domains of the leUALacin synthetase are substrate specific, while A1, A3, and A5 can accept alternative precursors to yield new molecules.
Pd-Catalyzed Acetoxylation of γ-C(sp3)-H Bonds of Amines Directed by a Removable Bts-Protecting Group.
Pd-catalyzed acetoxylation of γ-C(sp3)-H bonds directed by Bts-protected amines using inexpensive PhI(OAc)2 as oxidant is reported. The Bts-protecting group is easily introduced and removed under
Pd-catalyzed intramolecular C(sp2)-H amination of phenylalanine moieties in dipeptides: synthesis of indoline-2-carboxylate-containing dipeptides.
A palladium-catalyzed intramolecular C(sp2)-H amination of phenylalanine moieties in dipeptides is described, providing an appealing strategy for the post-synthetic modification of peptides.
Thiol-assisted one-pot synthesis of peptide/protein C-terminal thioacids from peptide/protein hydrazides at neutral conditions.
An efficient thiol-assisted one-pot synthesis of peptide/protein C-terminal thioacids was achieved by using peptide/protein hydrazides precursors at neutral pH and room temperature (about 20 °C). The
Synthesis of a series of novel chiral Lewis base catalysts and their application in promoting asymmetric hydrosilylation of β-enamino esters.
It is noteworthy that several cyclic substrates were hydrosilylated under the optimal conditions to give the cyclic β-amino esters with high yields, good diastereoselectivities as well as good ee values.
Autoxidation/Aldol Tandem Reaction of 2-Oxindoles with Ketones: A Green Approach for the Synthesis of 3-Hydroxy-2-Oxindoles.
In the presence of tetrabutylammonium fluoride and molecular sieves (MS) 4 Å in DMF, an efficient autoxidation reaction of 2-oxindoles with ketones under air at room temperature has been developed.
Pd-Catalyzed Site-Selective C(sp2)-H Olefination and Alkynylation of Phenylalanine Residues in Peptides.
Pd-catalyzed site-selective C(sp2)-H olefination and alkynylation of phenylalanine residues in peptides are described to provide appealing strategies for the postsynthetic modification of peptides.