Yong-sheng Gao

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In ovarian cancer patients, chemotherapy resistance is the principal factor restricting long-term treatment. Paclitaxel (Pac) has been previously reported to be a ligand to Toll-like receptor 4 (TLR4). It was determined that TLR4 signaling is divided into the following two pathways: Myeloid differentiation factor 88 (MyD88)-dependent and MyD88-independent.(More)
BACKGROUND Identifying novel tumor biomarkers to develop more effective diagnostic and therapeutic strategies for patients with ACC is urgently needed. The aim of the study was to compare the proteomic profiles between adrenocortical carcinomas (ACC) and normal adrenocortical tissues in order to identify novel potential biomarkers for ACC. METHODS The(More)
A 47-year-old woman presented with shortness of breath and edema of lower limbs for 3 months. Echocardiography showed an iso-echoic lesion in the right atrium and IVC (Fig. 1a), while CT revealed an intensely enhanced mass in the region above (Fig. 1b and c). Debulking was successfully completed and histo-pathologic diagnosis is consistent with angiofibroma(More)
BACKGROUND The urachus is a vestigial tubular structure that connects the urinary bladder to the allantois during early embryonic development. Urachal carcinoma develops in the urachus, which is an embryological remnant of the urogenital sinus and allantois. The estimated annual incidence of urachal carcinoma in the general population is 0.01% of all(More)
Toll-like receptor (TLR4) 4 is present in numerous cell types and serves as the first point of defense in the innate immune system. Single-nucleotide polymorphisms (SNPs) are present in a number TLR genes and have been associated with various infection and inflammation disorders. Asp299Gly and Thr399Ile, TLR4 SNPs, are associated with tumor progression. In(More)
PURPOSE (18)F-FLT-PET imaging was proposed as a tool for measuring in vivo tumor cell proliferation and detecting sub-volumes to propose escalation in radiotherapy. The aim of this study was to validate whether high FLT uptake areas in (18)F-FLT PET/CT are coincident with tumor cell proliferation distribution indicated by Ki-67 staining in non-small cell(More)
A 29-year old female with a history of isolated patent ductus arteriosus (PDA) ligation 14 years back, complained of increasing shortness of breath on exertion and hoarseness for 6 years. Chest radiography revealed a widened mediastinum (Fig. 1A). Computed tomography (CT) angiography showed a ductal pseu-doaneurysm and pulmonary arterial dilatation (Fig. 1B(More)
OBJECTIVE To explore the inhibitory effects on glucosylceramide synthase (GCS) expression and drug sensitivity in breast cancer cells by transfecting artificial microRNA targeting GCS. METHODS Two microRNA expression vectors targeting GCS were constructed and transfected into MCF-7/ADR cells via Lipofectamine 2000. The levels of GCS mRNA and protein were(More)