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In Situ Gelling Gelrite/Alginate Formulations as Vehicles for Ophthalmic Drug Delivery
TLDR
The overall results of this study revealed that the Gelrite/alginate mixture can be used as an in situ gelling vehicle to enhance ocular retention and was found to be almost non-irritant in the ocular irritancy test.
Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3K/Akt and Nrf2 Signaling Pathway
TLDR
The results suggest that PTS may activate endogenous cytoprotective mechanism against OGD-Rep induced oxidative injury via the activation of PI3K/Akt and Nrf2 signaling pathway.
Bioactivities and serum pharmacochemistry of Qi-Wei-Xiao-Yan-Tang
TLDR
It is demonstrated that XYT has significant anti-inflammatory and antibacterial properties, and calycosin-7-glucoside, sennoside A aloeemodin and rhein may be the biologically active substances of XYT.
Ginsenosides for the treatment of metabolic syndrome and cardiovascular diseases: Pharmacology and mechanisms.
TLDR
Current pharmacological effects of ginsenosides on MetS and CVDs, potential mechanisms and clinic trials, which will greatly contribute to the development of potential agents for related disease treatment are summarized.
Anti-platelet activity of panaxatriol saponins is mediated by suppression of intracellular calcium mobilization and ERK2/p38 activation
TLDR
It is proved that PTS is effective in anti-platelet aggregation, which may, at least in part, be related to the suppression of intracellular calcium mobilization and ERK2/p38 activation.
Proteomic Identification of Nrf2-Mediated Phase II Enzymes Critical for Protection of Tao Hong Si Wu Decoction against Oxygen Glucose Deprivation Injury in PC12 Cells
TLDR
THSWD's protection against oxygen-glucose deprivation-reperfusion (OGD-Rep) induced cell death was significantly attenuated by antioxidant response element (ARE) decoy oligonucleotides, suggesting the protection of THSWD may be likely regulated at least in part by Nrf2-mediated phase II enzymes.
MicroRNA-137 exerts protective effects on hypoxia-induced cell injury by inhibiting autophagy/mitophagy and maintaining mitochondrial function in breast cancer stem-like cells
TLDR
It is demonstrated here that the introduction of exogenous miR-137 promoted mitochondrial function, indicating that it may be a potential therapeutic target in BCSCs.
Traditional uses, botany, phytochemistry, pharmacology, separation and analysis technologies of Euonymus alatus (Thunb.) Siebold: A comprehensive review.
TLDR
This paper reviewed and summarized the integrated research progress of this medicinal plant and provided a comprehensive summary and comparison of traditional usages, botany, phytochemistry, pharmacology, toxicology, separation and analysis technologies of the E. alatus.
Natural Medicines for the Treatment of Epilepsy: Bioactive Components, Pharmacology and Mechanism
TLDR
Based on the different treatment mechanisms of natural drugs considered in this review, it is possible to select drugs clinically and improve the accuracy of medication and the cure rate is expected to compensate for the shortage of conventional epilepsy treatment drugs.
Investigation of Maillard reaction involvement in the steam processing of Panax Notoginseng root
Purpose: To explore the possible mechanism of Maillard reaction (MR) involvement in the steam processing of Panax notoginseng (PN) root. Methods: PN root was soaked in water for 24 h and then steamed
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