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Probing the local environment of target cells has been considered a challenging task due to the complexity of living cells. Here, we developed new single cell-based chip to investigate the intracellular and extracellular redox state of PC12 cells using spectroelectrochemical tool that combined surface-enhanced Raman scattering (SERS) and linear sweep(More)
We fabricate a nanoscale biomemory device composed of recombinant azurin on nanogap electrodes. For this, size-controllable nanogap electrodes are fabricated by photolithography, electron beam lithography, and surface catalyzed chemical deposition. Moreover, we investigate the effect of gap distance to optimize the size of electrodes for a biomemory device(More)
Myogloblin, a well-known metalloprotein, was immobilized on a gold surface using various chemical linkers to investigate the length effect of chemical linker on the electron transfer in protein layers, because chemical linkers play roles in the pathway that transfers the electron from the protein to the gold substrate and act as protein immobilization(More)
This paper describes all solid-state switched pulser for commercial air pollution control system using nonthermal pulsed plasma processing, for which a highly efficient and long life pulse power supply is required. The proposed pulser is composed of 30 series connections of pulse generating module (PGM) that can produce a 700 V/500 A/100 ns pulse with the(More)
We developed surface modification tools for the fabrication of a bioelectronic device which consists of a myoglobin monolayer self-assembled on an 11-MUA layer. To utilize a single protein as the active element, it was necessary to reduce protein aggregation on the protein layer in the nanobio electronic device, which was developed in our previous study and(More)
The fabrication method of nanoscale myoglobin monolayer using chemical linker is introduced in this study because control of amount and orientation of protein immobilized on electronic device is one of main issues to be solved for the realization of biomolecular electronic device. Myoglobin, metalloprotein, is selected as active material due to its(More)
We developed the nanoscale biofilm consisting of cytochrome f self-assembled on 2-MAA layer to apply bioelectronic devices. As cytochrome f has redox property, it can be possible to apply bioelectronic devices. The fabricated biofilm was confirmed by SPR and STM experiment. And the electrochemical property was checked by CV, CA, and STS.
The nanogap devices, which comprise multiple electrodes separated by a few to a few tens of nanometers, have opened up new possibilities in biomolecular sensing as well as various frontier electronics. One of the key aspects of the nanogap device research is how to control the gap distance following each specific needs of the gap structure. Here, we report(More)
The films organized with biomolecules and organic materials are important elements for developing bioelectronic devices according to their electron transfer property. Until now, several concepts of techniques have been accomplished to be used for developing biomemory devices. However it is difficult to detect the current signal from the electron transfer(More)
The novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 2 shows highly potent and broad cytotoxicities. Their cytotoxicities against human lung carcinoma A549, human chronic myelogenous leukemia K562, and human ovarian adenocarcinoma SK-OV-3 are compatible with doxorubicin. Compound 2p(More)