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Recommender systems are important building blocks in many of today's e-commerce applications including targeted advertising, personalized marketing and information retrieval. In recent years, the importance of contextual information has motivated many researchers to focus on designing systems that produce personalized recommendations in accordance with the(More)
[1] Based on 1–2 years of continuous observations of seismic ambient noise data obtained at more than 600 stations in and around Tibet, Rayleigh wave phase velocity maps are constructed from 10 s to 60 s period. A 3-D Vsv model of the crust and uppermost mantle is derived from these maps. The 3-D model exhibits significant apparently interconnected low(More)
Cytotoxic T lymphocyte antigen 4 (CTLA-4) is an essential negative regulator of T cell immune responses whose mechanism of action is the subject of debate. CTLA-4 shares two ligands (CD80 and CD86) with a stimulatory receptor, CD28. Here, we show that CTLA-4 can capture its ligands from opposing cells by a process of trans-endocytosis. After removal, these(More)
Cell-surface receptors frequently use scaffold proteins to recruit cytoplasmic targets, but the rationale for this is uncertain. Activated receptor tyrosine kinases, for example, engage scaffolds such as Shc1 that contain phosphotyrosine (pTyr)-binding (PTB) domains. Using quantitative mass spectrometry, here we show that mammalian Shc1 responds to(More)
Cotton is one of the most important crops for its natural textile fibers in the world. However, it often suffered from drought stress during its growth and development, resulting in a drastic reduction in cotton productivity. Therefore, study on molecular mechanism of cotton drought-tolerance is very important for increasing cotton production. To(More)
Using data from more than 2000 seismic stations from multiple networks arrayed through we perform ambient noise Rayleigh wave tomography across the entire region and earthquake tomography across parts of South China and Northeast China. We produce isotropic Rayleigh wave group and phase speed maps with uncertainty estimates from 8 to 50 sec period across(More)
The active form of vitamin D, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), has potent immunomodulatory properties that have promoted its potential use in the prevention and treatment of infectious disease and autoimmune conditions. A variety of immune cells, including macrophages, dendritic cells, and activated T cells express the intracellular vitamin D(More)
Two groups of antimicrobial peptides have been isolated from skin secretions of Bombina maxima. Peptides in the first group, named maximins 1, 2, 3, 4 and 5, are structurally related to bombinin-like peptides (BLPs). Unlike BLPs, sequence variations in maximins occurred all through the molecules. In addition to the potent antimicrobial activity,(More)
B-cell receptor (BCR) signaling activates a number of intracellular signaling molecules including phospholipase C-gamma2 (PLC-gamma2), which generates membrane diacylglycerol (DAG). DAG recruits both protein kinase C (PKC) and RasGRP family members to the membrane and contributes to their activation. We have hypothesized that membrane colocalization(More)