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BACKGROUND The Cancer Genome Atlas project (TCGA) has initiated the analysis of multiple samples of a variety of tumor types, starting with glioblastoma multiforme. The analytical methods encompass genomic and transcriptomic information, as well as demographic and clinical data about the sample donors. The data create the opportunity for a systematic(More)
We study black holes in the Hořava-Lifshitz gravity with a parameter λ. For 1/3 ≤ λ < 3, the black holes behave the Lifshitz black holes with dynamical exponent 0 < z ≤ 4, while for λ > 3, the black holes behave the Reissner-Nordström type black hole in asymptotically flat spacetimes. Hence, these all are quite different from the Schwarzschild-AdS black(More)
Several small molecules that inhibit the PI3 kinase (PI3K)-Akt signaling pathway are in clinical development. Although many of these molecules have been effective in preclinical models, it remains unclear whether this strategy alone will be sufficient to interrupt the molecular events initiated and maintained by signaling along the pathways because of the(More)
BACKGROUND The Cancer Genome Atlas (TCGA) project is a large-scale effort with the goal of identifying novel molecular aberrations in glioblastoma (GBM). METHODS Here, we describe an in-depth analysis of gene expression data and copy number aberration (CNA) data to classify GBMs into prognostic groups to determine correlates of subtypes that may be(More)
Chlorogenic acid, which belongs to the polyphenols, is an anti-oxidant and anti-obesity agent. In this study, we investigated the role of chlorogenic acid in inflammation. Anti-inflammatory effects of chlorogenic acid were examined in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophages and BV2 microglial cells. We observed the level of various(More)
Paclitaxel (Taxol) resistance remains a major obstacle for the successful treatment of ovarian cancer. MicroRNAs (miRNAs) have oncogenic and tumor suppressor activity and are associated with poor prognosis phenotypes. miRNA screenings for this drug resistance are needed to estimate the prognosis of the disease and find better drug targets. miRNAs that were(More)
The phosphatidylinositol-3-kinase (PI3K)/Akt oncogenic pathway is critical in glioblastomas. Loss of PTEN, a negative regulator of the PI3K pathway or activated PI3K/Akt pathway that drive increased proliferation, survival, neovascularization, glycolysis, and invasion is found in 70%-80% of malignant gliomas. Thus, PI3K is an attractive therapeutic target(More)
We introduce a new attractor mechanism to find the entropy for spherically symmetric extremal black holes. The key ingredient is to find a two-dimensional (2D) dilaton gravity with the dilaton potential V (φ). The condition of an attractor is given by ∇ 2 φ = V (φ 0) and ¯ R 2 = −V ′ (φ 0) and for a constant dilaton φ = φ 0 , these are also used to find the(More)
We apply the generalized uncertainty principle to the black hole thermodynamics. Here we have a black hole system with UV and IR cutoffs. In order to describe the system as a whole, we incorporate the UV thermodynamics with the IR thermodynamics by introducing the geometric means of thermodynamic quantities. As a result, we show that the minimal length(More)
CA125 as a biomarker of ovarian cancer is ineffective for the general population. The aim of this study was to evaluate multiplexed bead-based immunoassay of multiple ovarian cancer-associated biomarkers such as transthyretin and apolipoprotein A1, together with CA125, to improve the identification and evaluation of prognosis of ovarian cancer. We measured(More)