Yong Rak Kim

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Genetic mutation and pharmacological inhibition of Bruton's tyrosine kinase (Btk) both have been shown to prevent the development of collagen-induced arthritis (CIA) in mice, providing a rationale for the development of Btk inhibitors for treating rheumatoid arthritis (RA). In the present study, we characterized a novel Btk inhibitor,(More)
OBJECTIVE Bruton's tyrosine kinase (BTK) plays a critical role in B cell development and function. We recently described a selective BTK inhibitor, RN486, that blocks B cell receptor (BCR) and Fcγ receptor signaling and is efficacious in animal models of arthritis. The aim of this study was to examine the potential efficacy of BTK in systemic lupus(More)
INTRODUCTION Spleen tyrosine kinase (SYK) is a key integrator of intracellular signals triggered by activated immunoreceptors, including Bcell receptors (BCR) and Fc receptors, which are important for the development and function of lymphoid cells. Given the clinical efficacy of Bcell depletion in the treatment of rheumatoid arthritis and multiple(More)
The primary objective of this research is to evaluate the feasibility of several WMA mixtures as potential asphalt paving mixtures for Nebraska pavements. To that end, three well-known WMA additives (i.e., Sasobit, Evotherm, and Advera synthetic zeolite) were evaluated. For a more realistic evaluation of the WMA approaches, trial pavement sections of the(More)
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