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Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development
Disrupted ERK1/2 (MAPK3/MAPK1) MAPK signaling has been associated with several developmental syndromes in humans; however, mutations in ERK1 or ERK2 have not been described. We demonstrateExpand
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Dynamic patterns of apoptosis in the developing chicken heart
The outflow tract (OFT) is abnormal in many congenital heart defects. One critical mechanism for morphogenesis of this complex structure is apoptosis. Chicken embryos (stages 19–38; ED4–10) stainedExpand
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HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb.
Estrogen receptor alpha (ERalpha) plays a key role in mammary gland development and is implicated in breast cancer through the transcriptional regulation of genes linked to proliferation andExpand
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Expression of Lymphatic Markers During Avian and Mouse Cardiogenesis
The adult heart has been reported to have an extensive lymphatic system, yet the development of this important system during cardiogenesis is still largely unexplored. The nuclear‐localizedExpand
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Induction of quinone reductase by tamoxifen or DPN protects against mammary tumorigenesis
We have previously shown that estrogen receptor β (ERβ)‐mediated up‐regulation of quinone reductase (QR) is involved in the protection against estrogen‐induced mammary tumorigenesis. Our presentExpand
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Cited2, a coactivator of HNF4α, is essential for liver development
The transcriptional modulator Cited2 is induced by various biological stimuli including hypoxia, cytokines, growth factors, lipopolysaccharide (LPS) and flow shear. In this study, we report thatExpand
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Ethanol exposure alters early cardiac function in the looping heart: a mechanism for congenital heart defects?
Alcohol-induced congenital heart defects are frequently among the most life threatening and require surgical correction in newborns. The etiology of these defects, collectively known as fetal alcoholExpand
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HEXIM1 modulates vascular endothelial growth factor expression and function in breast epithelial cells and mammary gland
Recently, we found that mutation of the C-terminus of transcription factor hexamethylene bisacetamide-inducible protein 1 (HEXIM1) in mice leads to abnormalities in cardiovascular development becauseExpand
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Inhibition of metastasis by HEXIM1 through effects on cell invasion and angiogenesis
We report on the role of hexamethylene-bis-acetamide-inducible protein 1 (HEXIM1) as an inhibitor of metastasis. HEXIM1 expression is decreased in human metastatic breast cancers when compared withExpand
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Using optical coherence tomography to rapidly phenotype and quantify congenital heart defects associated with prenatal alcohol exposure
Background: The most commonly used method to analyze congenital heart defects involves serial sectioning and histology. However, this is often a time‐consuming process where the quantification ofExpand
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