Yong-Long Chen

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The boronic acid dipeptide bortezomib inhibits the chymotrypsin-like activity of the 26S proteasome and shows significant therapeutic efficacy in multiple myeloma. However, recent studies suggest that bortezomib may have more complex mechanisms of action in treating cancer. We report here that the endocytosis and lysosomal degradation of the receptor(More)
BACKGROUND Multiple myeloma (MM) is a disease of cell cycle dysregulation while cell cycle modulation can be a target for MM therapy. In this study we investigated the effects and mechanisms of action of a sesquiterpene lactone 6-O-angeloylplenolin (6-OAP) on MM cells. METHODOLOGY/PRINCIPAL FINDINGS MM cells were exposed to 6-OAP and cell cycle(More)
UNLABELLED This study considers a laboratory examination of the antioxidant performance of methanolic extracts from the leaves and stems of 3 common wild grapes (Vitis thunbergii, V. flexuosa, and V. kelungeusis) by various in vitro methods. It also seeks to identify the specific antioxidant constituent. Results revealed that, of these specimens, stem(More)
The objective of this study is to assess antioxidant activities of methanolic extracts from the leaves of 18 indigenous tree species in Taiwan. Results revealed that, among 18 species, Acer oliverianum exhibited the best free radical scavenging activities. The IC(50) values were 5.8 and 11.8 μg/mL on DPPH radical and superoxide radical scavenging(More)
Accumulated evidence indicates that the activating transcription factor 4 (atf4) is a developmentally relevant gene. Here, we report on the characterization of atf4 in Xenopus embryos, which is differentially expressed in the central nervous system, eyes, blood, and the pronephros, as well as in developing endodermal organs such as the stomach, duodenum,(More)
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