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Administration of protein and DNA biotherapeutics is limited by the need for hypodermic injection. Use of micron-scale needles to deliver drugs in a minimally invasive manner provides an attractive alternative, but application of this approach is limited by the need for suitable microneedle designs and fabrication methods. To address this need, this paper(More)
We have designed and fabricated a microneedle array with electrical functionality with the final goal of electroporating skin's epidermal cells to increase their transfection by DNA vaccines. The microneedle array was made of polymethylmethacrylate (PMMA) by micromolding technology from a polydimethylsiloxane (PDMS) mold, followed by metal deposition,(More)
We report a fabrication approach for three-dimensional (3-D) microstructures having functional metal patterns by using inclined UV lithography and 3-D metal transfer micromolding. Inclined rotational UV exposure using SU-8 has been exploited to simultaneously generate gradually varying 3-D structures with different heights in a single mask. For 3-D metal(More)
We report a replica molding process for simultaneously forming a three dimensional metal pattern on the surface of molded polymer microstructures. This technique uses noncovalent surface forces to guide the transfer of thin metal films from the three dimensional features of high aspect ratio poly͑dimethylsiloxane͒ micromolds to polymeric replicates. The(More)
This article presents a new method for fabricating highly conductive gold nanostructures within a polymeric matrix with subwavelength resolution. The nanostructures are directly written in a gold precursor-doped photoresist using a femtosecond pulsed laser. The laser energy is absorbed by a two-photon dye, which induces simultaneous reduction of gold in the(More)
— A novel Ka-band surface micromachined air-elevated patch antenna is designed, fabricated and characterized. It demonstrates a 10.5% 10-dB fractional bandwidth and 9.5 dBi directivity for an elevation of 600 µm. The elevated patch is fed by a vertical epoxy-core metal-coated micromachined probe and supported by several epoxy posts underneath. By the unique(More)
We designed electrospun polycaprolactone mats consisting of nanofibers and microbeads for extended delivery of dexamethasone. Thin flexible dexamethasone loaded polycaprolactone mats were prepared by electrospinning. The solvents, polymer loading, voltage and tip-to-collector distance were varied to explore the effects on microstructure of the mats. The(More)
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