Yong Kiam Tan

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Twelve newborn infants were given morphine intravenously for postoperative analgesia. They received a continuous infusion of 6.2 to 40 micrograms/kg/hr for 9 to 105 hours (mean +/- SEM 59.5 +/- 10.2 hours); in four the infusion was preceded by a loading dose of 50 to 100 micrograms/kg. Morphine plasma concentrations correlated with the rate of infusion, but(More)
Thirty-two 5- to 17-year-old children who had severe, acute asthma were randomly assigned to receive either high doses (0.15 mg/kg of body weight per dose) or low doses (0.05 mg/kg of body weight per dose) of nebulized albuterol every 20 minutes for six doses. Compared with the low-dose regimen, the high-dose regimen resulted in significantly greater(More)
Salbutamol was administered to sixteen healthy male volunteers intravenously and by mouth in liquid, tablet, and capsule form using a Latin-Squares design. Pharmacokinetic parameters from intravenous data were similar to previously reported values obtained with oral administration, with a mean terminal half-life of 3.8 h and a mean clearance of 439 ml X(More)
The effects of iv salbutamol on respiratory mechanics were studied in six infants with bronchopulmonary dysplasia. Salbutamol was infused at a dose of 30 micrograms/kg over 30 min in five infants; a sixth infant received 66.7 micrograms/kg over 4 min. Salbutamol caused improvement in total respiratory system compliance and in airflow resistance. There was(More)
Thirty-three children and adolescents from 5 to 17 years of age with moderate to severe acute asthma were given nebulized albuterol therapy in either a high (0.30 mg/kg body weight) or standard (0.15 mg/kg) dose administered at three hourly intervals in a randomized double-blind study. The high-dose hourly regimen resulted in significantly greater(More)
Enantiomers of salbutamol, extracted from human urine, were successfully separated and quantitated by high-performance liquid chromatography with electrochemical detection. This direct resolution was accomplished using a chiral alpha 1-acid glycoprotein column (EnantioPac) maintained at 0 degrees C and a mobile phase consisting of a 0.1% (v/v) triethylamine(More)
We studied the disposition of inhaled salbutamol in adolescents with cystic fibrosis (CF) and compared it with the pharmacokinetics of the drug given by the intravenous and inhaled routes in healthy adults. After inhalation of salbutamol, CF patients had a significantly larger area under the concentration-time curve derived from amounts of drug in the(More)
When doing an interactive proof about a piece of software, it is important that the underlying programming language's semantics does not make the proof unnecessarily difficult or unwieldy. Both small-step and big-step semantics are commonly used, and the latter is typically given by an inductively defined relation. In this paper, we consider an alternative:(More)
Most of the conventional electric powered wheelchairs are using joystick as a used input mode of control to maneuver the powered wheelchairs. The drawback of joystick control is that it is not suitable for physical disabled person who cannot control their movements especially the hands. The proposed voice-activated powered wheelchair supplementary with(More)