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We present a novel approach for interactive content-aware image resizing. The resizing is performed on warping a triangular mesh over the image, which captures the image saliency information as well as the underlying image features. The warped triangular mesh and the horizontal and vertical scales of all triangles are simultaneously obtained by a quadratic(More)
Hepatic stellate cells (HSCs) activation is an essential event during liver fibrogenesis. A major pathway is the transition of HSCs into hepatic myofibroblasts. The methyl-CpG-binding protein MeCP2 which promotes repressed chromatin structure is selectively detected in myofibroblasts of diseased liver. Overexpression of this protein results in an increase(More)
Trastuzumab resistance is leading cause of mortality in HER2-positive breast cancers, and the role of TGF-β-induced epithelial-mesenchymal transition (EMT) in trastuzumab resistance is well established, but the involvement of lncRNAs in trastuzumab resistance is still unknown. Here, we generated trastuzumab-resistant breast cancer cells with increased(More)
Generating B cell-deficient mutant is the first step to produce human antibody repertoires in large animal models. In this study, we applied the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) system to target the JH region of the pig IgM heavy chain gene which is crucial for B cell development and differentiation.(More)
Thirty-four samples of domestic wheat and barley grains, collected from eight prefectures of different locations in Japan and previously determined to be positive for deoxynivalenol (DON), nivalenol (NIV) and/or zearalenone (ZEA), were analysed for acetylated derivatives of DON and NIV by gas chromatography-mass spectrometry. In addition to DON and NIV,(More)
OBJECTIVE The objective of the present study was to investigate the feasibility and reliability of sintering alumina and zirconia-based all-ceramic materials through a recently introduced microwave heating technique. The variation of crystal phases, the growth of grain sizes and microstructural features of these materials were evaluated after sintering. (More)
This paper proposes an enhanced adaptive forward error correction (EAFEC) algorithm based on cross- layer design for wireless media streaming, in the hope that the media could be played on receivers with high quality. This algorithm, which uses the Poisson process to predict the current network condition, can adjust the sending rate of MPEG video frame(More)
AIM To study the pharmacokinetics of leflunomide in Chinese healthy volunteers. METHODS A single (20, 40, and 60 mg) and 30-d -repeated (20 mg/d) oral doses of leflunomide were performed on 18 (12 males and 6 females) and 6 (4 males and 2 females) Chinese healthy volunteers respectively. A771726, the active metabolite of leflunomide, in serum was(More)
Rheumatoid arthritis (RA) is a chronic symmetrical autoimmune disease of unknown etiology that affects primarily the diarthrodial joints. Characteristic features of RA pathogenesis are synovial inflammation and proliferation accompanied by cartilage erosion and bone loss. Fibroblast-like synoviocytes (FLS) display an important role in the pathogenesis of(More)