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Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor: the p75 neurotrophin receptor (p75(NTR)) and tyrosine kinase receptors (Trks). Whereas p75(NTR) binds to all NTs, the Trk subtypes are specific for each NT. The(More)
People tend to form an internal model of systems and how they work. An accurate mental model helps promote user experience and performance. As a result, interface designs that are based on a users mental model have been discussed frequently. However, the concept of a mental model has varying interpretations and is considered difficult to operationalize.(More)
His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity and are found in all kingdoms of life. Although HNH endonucleases from mesophiles have been widely investigated, the biochemical functions of HNH endonucleases from thermophilic bacteriophages remain unknown.(More)
Sulfolobus synthesizes large amounts of small chromatin proteins Cren7 and Sul7d. The two proteins share overall structural similarity, but differ distinctly in the DNA-binding region between β3- and β4-strands. While Sul7d possesses a hinge of two amino acid residues, Cren7 contains a flexible seven-residue loop (loop β3–β4) in the region. Here, we report(More)
In tradition probability statistics model, speaker verification threshold is instability in different test situations. A novel speaker verification method based on Support Vector Data Description (SVDD) is proposed to remedy the defect of probability statistics model. To simplify the threshold value setting and improve the robustness and recognition(More)
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