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The cell division axis determines the future positions of daughter cells and is therefore critical for cell fate. The positioning of the division axis has been mostly studied in systems such as embryos or yeasts, in which cell shape is well defined. In these cases, cell shape anisotropy and cell polarity affect spindle orientation. It remains unclear(More)
Control of the establishment of cell polarity is an essential function in tissue morphogenesis and renewal that depends on spatial cues provided by the extracellular environment. The molecular role of cell-cell or cell-extracellular matrix (ECM) contacts on the establishment of cell polarity has been well characterized. It has been hypothesized that the(More)
Cells display a large variety of shapes when plated in classical culture conditions despite their belonging to a common cell type. These shapes are transitory, since cells permanently disassemble and reassemble their cytoskeleton while moving. Adhesive micropatterns are commonly used to confine cell shape within a given geometry. In addition the(More)
The SECURE project is investigating the design of security mechanisms for pervasive computing based on the human notion of trust. Our work addresses how entities that encounter each other in unfamiliar, pervasive computing environments can overcome initial suspicion to allow secure collaboration to take place. 1 Overview At present most substantial,(More)
Distributed sensor networks are quickly gaining recognition as viable embedded computing platforms. Current techniques for programming sensor networks are cumbersome, inflexible, and low-level. This paper introduces EnviroTrack, an object-based distributed middleware system that raises the level of programming abstraction by providing a convenient and(More)
The possibility of a massive, networked infrastructure of diverse entities partaking in collaborative applications with each other increases more and more with the proliferation of mobile devices and the development of ad hoc networking technologies. In this context, traditional security measures do not scale well. We aim to develop trust-based security(More)
Data prefetching is an effective way to bridge the increasing performance gap between processor and memory. As computing power is increasing much faster than memory performance, we suggest that it is time to have a dedicated cache to store data access histories and to serve prefetching to mask data access latency effectively. We thus propose a new cache(More)
We present a novel framework which can efficiently evaluate approximate Boolean set operations for B-rep models by highly parallel algorithms. This is achieved by taking axis-aligned surfels of Layered Depth Images (LDI) as a bridge and performing Boolean operations on the structured points. As compared with prior surfel-based approaches, this paper has(More)
Microprocessor architecture has entered the multicore era. Recently, Hill and Marty presented a pessimistic view of multicore scalability. Their analysis was based on Amdahl's law (i.e. fixed-workload condition) and challenged readers to develop better models. In this study, we analyze multicore scalability under fixed-time and memory-bound conditions and(More)
We investigated electrophysiological changes in chronically axotomized and neighboring intact dorsal root ganglion (DRG) neurons in rats after either a peripheral axotomy consisting of an L5 spinal nerve ligation (SNL) or a central axotomy produced by an L5 partial rhizotomy (PR). SNL produced lasting hyperalgesia to punctate indentation and tactile(More)