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SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing protein which, when mutated in mice, results in immune system disorders and multi-organ inflammation. Here we report that SHARPINExpand
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Melanoma genome sequencing reveals frequent PREX2 mutations
Melanoma is notable for its metastatic propensity, lethality in the advanced setting and association with ultraviolet exposure early in life. To obtain a comprehensive genomic view of melanoma inExpand
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Genomic Classification of Cutaneous Melanoma
We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish aExpand
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Post-translational modifications in signal integration
Post-translational modifications of proteins and the domains that recognize these modifications have central roles in creating a highly dynamic relay system that reads and responds to alterations inExpand
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Cbl promotes clustering of endocytic adaptor proteins
The ubiquitin ligases c-Cbl and Cbl-b play a crucial role in receptor downregulation by mediating multiple monoubiquitination of receptors and promoting their sorting for lysosomal degradation. TheirExpand
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Atypical Polyproline Recognition by the CMS N-terminal Src Homology 3 Domain*
The CIN85/CMS (human homologs of mouse SH3KBP1/CD2AP) family of endocytic adaptor proteins has the ability to engage multiple effectors and couple cargo trafficking with the cytoskeleton. CIN85 andExpand
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Caspase-8 Is Involved in Neovascularization-Promoting Progenitor Cell Functions
Objective—Endothelial progenitor cells (EPCs) comprise a heterogeneous population of cells, which improve therapeutic neovascularization after ischemia. The neovascularization-promoting potential ofExpand
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Author Correction: Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer
In the version of this article originally published, information regarding several funding sources was omitted from the Acknowledgements section. The following sentences should have been included:Expand
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Reply to “The binding stoichiometry of CIN85 SH3 domain A and Cbl-b”
891 which recognizes a proline-arginine motif in the serine/ threonine kinase PAK6. Moreover, the ability of Cbl and CIN85 to form higherorder oligomers is required for their ability to mediateExpand
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