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PKR, an interferon (IFN)-inducible protein kinase activated by double-stranded RNA, inhibits translation by phosphorylating the initiation factor eIF2alpha chain. We show that human IFN-gamma mRNA uses local activation of PKR in the cell to control its own translation yield. IFN-gamma mRNA activates PKR through a pseudoknot in its 5' untranslated region.(More)
The RNA-activated protein kinase PKR is an intracellular sensor of stress. Double-stranded RNA produced during viral replication activates PKR, which phosphorylates the α-subunit of eukaryotic initiation factor 2 (eIF2α) to inhibit translation, resulting in apoptosis of infected cells and preventing spread of the virus. Intracellular levels of PKR rise upon(More)
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